Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2232735..2233633 Replicon chromosome
Accession NZ_CP018778
Organism Mycobacterium tuberculosis strain DK9897

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag BTU11_RS10845 Protein ID WP_003410001.1
Coordinates 2232735..2233295 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag BTU11_RS10850 Protein ID WP_003410003.1
Coordinates 2233292..2233633 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTU11_RS10810 2227904..2228557 - 654 WP_003409976.1 cutinase Cfp21 -
BTU11_RS10815 2228672..2228902 + 231 WP_003409980.1 DUF167 domain-containing protein -
BTU11_RS10820 2228987..2229898 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
BTU11_RS10825 2230007..2230606 + 600 WP_003409989.1 L-lysine exporter -
BTU11_RS10830 2231022..2231450 + 429 WP_003409992.1 cellulose-binding protein -
BTU11_RS10835 2231676..2232215 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
BTU11_RS10845 2232735..2233295 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
BTU11_RS10850 2233292..2233633 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
BTU11_RS10855 2233719..2233976 + 258 WP_003410006.1 hypothetical protein -
BTU11_RS10860 2233877..2234212 - 336 WP_003410009.1 dehydrogenase -
BTU11_RS10865 2234301..2234645 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
BTU11_RS10870 2234639..2234887 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
BTU11_RS10875 2234987..2237302 - 2316 WP_003899120.1 cation transporter ATPase CptG -
BTU11_RS10880 2237299..2237571 - 273 WP_003410017.1 DUF1490 family protein -
BTU11_RS10885 2237624..2237980 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T70481 WP_003410001.1 NZ_CP018778:c2233295-2232735 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T70481 NZ_CP018778:c2233295-2232735 [Mycobacterium tuberculosis]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT70481 WP_003410003.1 NZ_CP018778:c2233633-2233292 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT70481 NZ_CP018778:c2233633-2233292 [Mycobacterium tuberculosis]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References