Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1045238..1045752 Replicon chromosome
Accession NZ_CP018776
Organism Staphylococcus condimenti strain StO 2014-01

Toxin (Protein)


Gene name mazF Uniprot ID A0A3G4R0E2
Locus tag BTZ13_RS04720 Protein ID WP_075140914.1
Coordinates 1045402..1045752 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID B9DMI8
Locus tag BTZ13_RS04715 Protein ID WP_015900820.1
Coordinates 1045238..1045405 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTZ13_RS13215 1041402..1041629 + 228 WP_165380056.1 PH domain-containing protein -
BTZ13_RS04695 1041622..1043094 + 1473 WP_075140913.1 PH domain-containing protein -
BTZ13_RS04700 1043099..1043584 + 486 WP_063164645.1 PH domain-containing protein -
BTZ13_RS04705 1043586..1043939 + 354 WP_047132377.1 holo-ACP synthase -
BTZ13_RS04710 1044003..1045157 + 1155 WP_047132378.1 alanine racemase -
BTZ13_RS04715 1045238..1045405 + 168 WP_015900820.1 hypothetical protein Antitoxin
BTZ13_RS04720 1045402..1045752 + 351 WP_075140914.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BTZ13_RS04725 1046093..1047094 + 1002 WP_047133046.1 PP2C family protein-serine/threonine phosphatase -
BTZ13_RS04730 1047171..1047497 + 327 WP_015900817.1 anti-sigma factor antagonist -
BTZ13_RS04735 1047499..1047978 + 480 WP_047133045.1 anti-sigma B factor RsbW -
BTZ13_RS04740 1047953..1048723 + 771 WP_047133044.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13075.18 Da        Isoelectric Point: 10.0708

>T70445 WP_075140914.1 NZ_CP018776:1045402-1045752 [Staphylococcus condimenti]
MMRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TVDKKRLKEKLTYLSDEKMKEIDNAIQISLGLTHRN

Download         Length: 351 bp

>T70445 NZ_CP018776:1045402-1045752 [Staphylococcus condimenti]
ATGATGAGGAGAGGCGATGTTTACTTAGCTGATTTATCGCCAGTGCAAGGTTCTGAACAAGGGGGAGTTAGGCCTGTTGT
AATTATACAAAACGACACTGGAAATAAGTATAGTCCAACAGTCATTGTAGCTGCAATTACTGGACGGATTAATAAAGCAA
AAATTCCTACTCATGTTGAAATTGAAAAAAGTAAATATAAATTGGACAAAGATTCAGTTATTTTACTAGAACAGATAAGA
ACAGTCGATAAAAAGCGACTTAAAGAAAAACTGACATATTTATCAGACGAAAAGATGAAAGAAATTGATAATGCGATTCA
AATCAGCTTAGGCTTGACACATCGCAATTAA

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6211.75 Da        Isoelectric Point: 3.6836

>AT70445 WP_015900820.1 NZ_CP018776:1045238-1045405 [Staphylococcus condimenti]
MSTFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFSVECEACDCNESYLAFDKDE

Download         Length: 168 bp

>AT70445 NZ_CP018776:1045238-1045405 [Staphylococcus condimenti]
ATGTCAACTTTTAATCAGAATAGAAGTTATAGTTTAGAACAGTCACTGAAAGAAGGCTATGCACAGATGGCTGACTTAAA
TCTCTCCCTCGCAACGGAGGCATTTTCAGTAGAATGTGAAGCCTGTGATTGCAATGAATCATATTTAGCTTTTGACAAGG
ATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G4R0E2

Antitoxin

Source ID Structure
AlphaFold DB A0A380F5Y4

References