Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1031891..1032402 Replicon chromosome
Accession NZ_CP018776
Organism Staphylococcus condimenti strain StO 2014-01

Toxin (Protein)


Gene name TsdT Uniprot ID A0A143PEZ9
Locus tag BTZ13_RS04655 Protein ID WP_047132367.1
Coordinates 1032196..1032402 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID B9DMH6
Locus tag BTZ13_RS04650 Protein ID WP_015900833.1
Coordinates 1031891..1032184 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTZ13_RS04625 1027257..1027895 + 639 WP_047132363.1 thiamine phosphate synthase -
BTZ13_RS04630 1027984..1028859 + 876 WP_047132364.1 membrane protein insertase YidC -
BTZ13_RS04635 1028970..1029482 + 513 WP_047132365.1 GNAT family N-acetyltransferase -
BTZ13_RS04640 1029573..1030220 - 648 WP_047132366.1 HD domain-containing protein -
BTZ13_RS04645 1030245..1031726 - 1482 WP_075140912.1 cardiolipin synthase -
BTZ13_RS04650 1031891..1032184 + 294 WP_015900833.1 copper-sensing transcriptional repressor CsoR Antitoxin
BTZ13_RS04655 1032196..1032402 + 207 WP_047132367.1 cation transporter Toxin
BTZ13_RS04660 1032417..1032626 + 210 WP_047132368.1 copper ion binding protein -
BTZ13_RS04665 1032723..1034924 + 2202 WP_047132369.1 heavy metal translocating P-type ATPase -
BTZ13_RS13210 1035000..1035140 + 141 WP_165380001.1 hypothetical protein -
BTZ13_RS04670 1035220..1036431 - 1212 WP_047132370.1 rod shape-determining protein RodA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(27-65)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7815.73 Da        Isoelectric Point: 4.1353

>T70444 WP_047132367.1 NZ_CP018776:1032196-1032402 [Staphylococcus condimenti]
MQNSVIKIDGMETEEEQHKLHQHLIEMTGVTAVQVDLDSNEIKISYETPVNLNNLEKEIYDAGYQILN

Download         Length: 207 bp

>T70444 NZ_CP018776:1032196-1032402 [Staphylococcus condimenti]
ATGCAAAACAGTGTAATTAAAATTGATGGAATGGAAACTGAAGAAGAACAGCATAAATTACATCAACATCTTATAGAAAT
GACAGGTGTAACTGCAGTACAAGTAGATTTGGATTCAAATGAAATCAAAATCAGTTACGAAACACCTGTAAATCTCAATA
ATCTTGAAAAAGAAATCTATGATGCGGGTTATCAAATATTAAATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11132.76 Da        Isoelectric Point: 6.4862

>AT70444 WP_015900833.1 NZ_CP018776:1031891-1032184 [Staphylococcus condimenti]
MTENDKAHHSEQIKSNLKARLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAVRLLDHHMKGCIMHKVEDGHA
EEAMEELLVTVQKLIKD

Download         Length: 294 bp

>AT70444 NZ_CP018776:1031891-1032184 [Staphylococcus condimenti]
ATGACCGAAAATGACAAAGCACATCATTCAGAACAAATTAAGTCCAACTTGAAAGCAAGACTCAACCGTATTGAGGGGCA
AGTCAGAGCAATTAACCGAATGATTGAAGAAGATGTTTATTGTGATGATGTACTTACACAAATCCGTGCAACACGTTCAG
CCTTGAACAGTGTAGCAGTACGATTGCTTGATCACCATATGAAAGGTTGTATCATGCATAAAGTTGAGGATGGTCACGCT
GAAGAAGCAATGGAAGAATTGCTTGTTACCGTTCAAAAATTAATTAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A143PEZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A380F6K8

References