Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1117053..1117850 Replicon chromosome
Accession NZ_CP018768
Organism Staphylococcus aureus strain UCI 28 isolate ST5

Toxin (Protein)


Gene name - Uniprot ID A0A6B0C7N0
Locus tag BSG37_RS05630 Protein ID WP_000525009.1
Coordinates 1117053..1117514 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0C2LD36
Locus tag BSG37_RS05635 Protein ID WP_001260487.1
Coordinates 1117527..1117850 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSG37_RS05595 1112166..1112648 + 483 WP_000401377.1 pantetheine-phosphate adenylyltransferase -
BSG37_RS05600 1112710..1113849 - 1140 WP_000843611.1 nucleotidyltransferase -
BSG37_RS05605 1113976..1114533 + 558 WP_000872158.1 DUF177 domain-containing protein -
BSG37_RS05615 1114613..1114786 + 174 WP_000290472.1 50S ribosomal protein L32 -
BSG37_RS05620 1114903..1116288 - 1386 WP_000861313.1 recombinase family protein -
BSG37_RS05625 1116532..1117035 - 504 WP_000825944.1 hypothetical protein -
BSG37_RS05630 1117053..1117514 - 462 WP_000525009.1 hypothetical protein Toxin
BSG37_RS05635 1117527..1117850 - 324 WP_001260487.1 helix-turn-helix domain-containing protein Antitoxin
BSG37_RS05640 1118014..1118262 + 249 WP_000272859.1 helix-turn-helix domain-containing protein -
BSG37_RS05645 1118275..1118721 + 447 WP_000435350.1 hypothetical protein -
BSG37_RS15255 1118755..1118916 + 162 WP_001153176.1 hypothetical protein -
BSG37_RS15260 1118877..1119047 - 171 WP_001280594.1 hypothetical protein -
BSG37_RS05650 1119489..1119674 + 186 WP_000933364.1 helix-turn-helix transcriptional regulator -
BSG37_RS05655 1119676..1120416 + 741 WP_001606750.1 phage antirepressor KilAC domain-containing protein -
BSG37_RS05660 1120592..1120822 - 231 WP_000395455.1 hypothetical protein -
BSG37_RS15265 1120872..1121018 + 147 WP_000230553.1 hypothetical protein -
BSG37_RS05665 1121002..1121163 + 162 WP_000066021.1 DUF1270 family protein -
BSG37_RS05670 1121255..1121515 + 261 WP_000291089.1 DUF1108 family protein -
BSG37_RS05675 1121525..1121746 + 222 WP_000815401.1 DUF2483 family protein -
BSG37_RS05680 1121739..1122527 + 789 WP_001606751.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1109741..1158659 48918


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18060.39 Da        Isoelectric Point: 4.5941

>T70429 WP_000525009.1 NZ_CP018768:c1117514-1117053 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T70429 NZ_CP018768:c1117514-1117053 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCTGTTCCATTACGCGAAATTGTAGAAGCTTATAATTATGGCGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATACAAAAAGATATATGGTATTGGTACCC
ACTACGGCGAGTATTCTATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12431.09 Da        Isoelectric Point: 9.3811

>AT70429 WP_001260487.1 NZ_CP018768:c1117850-1117527 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT70429 NZ_CP018768:c1117850-1117527 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAGA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGTGCA
GCTCATTTAGAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B0C7N0

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LD36

References