Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 875761..876238 Replicon chromosome
Accession NZ_CP018768
Organism Staphylococcus aureus strain UCI 28 isolate ST5

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag BSG37_RS04340 Protein ID WP_000052076.1
Coordinates 875761..875949 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag BSG37_RS04345 Protein ID WP_001059690.1
Coordinates 875978..876238 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSG37_RS04310 871755..872276 + 522 WP_000824482.1 hypothetical protein -
BSG37_RS04315 872617..873303 + 687 WP_000141557.1 thermonuclease family protein -
BSG37_RS04320 873660..873860 + 201 WP_001059082.1 cold-shock protein -
BSG37_RS04325 874352..874570 - 219 WP_000005886.1 hypothetical protein -
BSG37_RS04330 874647..874916 - 270 WP_001004398.1 hypothetical protein -
BSG37_RS04335 875004..875573 - 570 WP_001106658.1 hypothetical protein -
BSG37_RS04340 875761..875949 - 189 WP_000052076.1 hypothetical protein Toxin
BSG37_RS04345 875978..876238 - 261 WP_001059690.1 hypothetical protein Antitoxin
BSG37_RS04350 876579..876782 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
BSG37_RS04355 876779..877015 - 237 WP_000349581.1 hypothetical protein -
BSG37_RS04360 877240..877821 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
BSG37_RS04365 877894..878511 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
BSG37_RS04370 878666..879160 - 495 WP_000569883.1 GNAT family N-acetyltransferase -
BSG37_RS04375 879559..879981 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
BSG37_RS04380 880129..880845 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T70428 WP_000052076.1 NZ_CP018768:c875949-875761 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T70428 NZ_CP018768:c875949-875761 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT70428 WP_001059690.1 NZ_CP018768:c876238-875978 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT70428 NZ_CP018768:c876238-875978 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References