Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2243461..2243975 Replicon chromosome
Accession NZ_CP018766
Organism Staphylococcus aureus strain UCI62

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag BSG38_RS11750 Protein ID WP_000581792.1
Coordinates 2243461..2243670 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag BSG38_RS11755 Protein ID WP_000138932.1
Coordinates 2243682..2243975 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSG38_RS11730 2238969..2240327 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
BSG38_RS11735 2240342..2241412 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
BSG38_RS11740 2241730..2242932 + 1203 WP_001109939.1 rod shape-determining protein RodA -
BSG38_RS11745 2243196..2243333 - 138 WP_000828354.1 hypothetical protein -
BSG38_RS11750 2243461..2243670 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
BSG38_RS11755 2243682..2243975 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
BSG38_RS11760 2244141..2245625 + 1485 WP_000571549.1 cardiolipin synthase -
BSG38_RS11765 2245653..2246300 + 648 WP_001187630.1 HD domain-containing protein -
BSG38_RS11780 2247213..2248085 - 873 WP_000725802.1 membrane protein insertase YidC -
BSG38_RS11785 2248171..2248812 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T70421 WP_000581792.1 NZ_CP018766:c2243670-2243461 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T70421 NZ_CP018766:c2243670-2243461 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT70421 WP_000138932.1 NZ_CP018766:c2243975-2243682 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT70421 NZ_CP018766:c2243975-2243682 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References