Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1642395..1643183 Replicon chromosome
Accession NZ_CP018766
Organism Staphylococcus aureus strain UCI62

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag BSG38_RS08360 Protein ID WP_000525004.1
Coordinates 1642722..1643183 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag BSG38_RS08355 Protein ID WP_000333630.1
Coordinates 1642395..1642709 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSG38_RS08295 1637537..1638703 - 1167 WP_000762547.1 DUF2800 domain-containing protein -
BSG38_RS08300 1638700..1639062 - 363 WP_031785938.1 hypothetical protein -
BSG38_RS08305 1639077..1639400 - 324 WP_000175001.1 hypothetical protein -
BSG38_RS08310 1639479..1639640 - 162 WP_001285954.1 DUF1270 domain-containing protein -
BSG38_RS08315 1639653..1639916 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
BSG38_RS08320 1639941..1640156 - 216 WP_001097552.1 hypothetical protein -
BSG38_RS08325 1640211..1640576 + 366 WP_001128433.1 hypothetical protein -
BSG38_RS08330 1640545..1640790 - 246 WP_001025401.1 DUF2829 domain-containing protein -
BSG38_RS08335 1640846..1641055 + 210 WP_000642492.1 hypothetical protein -
BSG38_RS08340 1641045..1641188 - 144 WP_000939498.1 hypothetical protein -
BSG38_RS08345 1641217..1641993 - 777 WP_001148544.1 Rha family transcriptional regulator -
BSG38_RS08350 1642007..1642243 - 237 WP_001121027.1 helix-turn-helix domain-containing protein -
BSG38_RS08355 1642395..1642709 + 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
BSG38_RS08360 1642722..1643183 + 462 WP_000525004.1 hypothetical protein Toxin
BSG38_RS08365 1643201..1643785 + 585 WP_000825948.1 hypothetical protein -
BSG38_RS08370 1644015..1644161 + 147 WP_001013104.1 hypothetical protein -
BSG38_RS08375 1644158..1644772 - 615 WP_000191459.1 hypothetical protein -
BSG38_RS08380 1644898..1646103 + 1206 WP_020444721.1 site-specific integrase -
BSG38_RS08385 1646185..1648173 - 1989 WP_033862636.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1600815..1663728 62913


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T70413 WP_000525004.1 NZ_CP018766:1642722-1643183 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T70413 NZ_CP018766:1642722-1643183 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT70413 WP_000333630.1 NZ_CP018766:1642395-1642709 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT70413 NZ_CP018766:1642395-1642709 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References