Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 894614..895091 Replicon chromosome
Accession NZ_CP018766
Organism Staphylococcus aureus strain UCI62

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag BSG38_RS04475 Protein ID WP_000052076.1
Coordinates 894614..894802 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag BSG38_RS04480 Protein ID WP_001059690.1
Coordinates 894831..895091 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSG38_RS04445 890608..891129 + 522 WP_000824482.1 hypothetical protein -
BSG38_RS04450 891470..892156 + 687 WP_000141557.1 thermonuclease family protein -
BSG38_RS04455 892513..892713 + 201 WP_001059082.1 cold-shock protein -
BSG38_RS04460 893205..893423 - 219 WP_000005886.1 hypothetical protein -
BSG38_RS04465 893500..893769 - 270 WP_001004398.1 hypothetical protein -
BSG38_RS04470 893857..894426 - 570 WP_001106658.1 hypothetical protein -
BSG38_RS04475 894614..894802 - 189 WP_000052076.1 hypothetical protein Toxin
BSG38_RS04480 894831..895091 - 261 WP_001059690.1 hypothetical protein Antitoxin
BSG38_RS04485 895432..895635 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
BSG38_RS04490 895632..895868 - 237 WP_000349581.1 hypothetical protein -
BSG38_RS04495 896093..896674 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
BSG38_RS04500 896747..897364 - 618 WP_031785906.1 LysE/ArgO family amino acid transporter -
BSG38_RS04505 897519..898013 - 495 WP_000569883.1 GNAT family N-acetyltransferase -
BSG38_RS04510 898412..898834 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
BSG38_RS04515 898982..899698 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T70409 WP_000052076.1 NZ_CP018766:c894802-894614 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T70409 NZ_CP018766:c894802-894614 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT70409 WP_001059690.1 NZ_CP018766:c895091-894831 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT70409 NZ_CP018766:c895091-894831 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References