Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1257810..1258303 Replicon chromosome
Accession NZ_CP018763
Organism Pediococcus acidilactici strain BCC1

Toxin (Protein)


Gene name relE Uniprot ID A0A1L6HC80
Locus tag BTW26_RS06225 Protein ID WP_075140069.1
Coordinates 1258037..1258303 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1L6HAU1
Locus tag BTW26_RS06220 Protein ID WP_075140068.1
Coordinates 1257810..1258040 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTW26_RS11020 1252993..1253271 - 279 WP_075140063.1 hypothetical protein -
BTW26_RS06195 1253571..1254161 - 591 WP_075140064.1 hypothetical protein -
BTW26_RS06200 1254358..1255305 - 948 WP_075140065.1 hypothetical protein -
BTW26_RS06205 1255437..1256009 - 573 WP_075140066.1 hypothetical protein -
BTW26_RS06210 1256022..1256942 - 921 WP_075140067.1 DUF4868 domain-containing protein -
BTW26_RS06215 1257296..1257680 - 385 Protein_1191 hypothetical protein -
BTW26_RS06220 1257810..1258040 + 231 WP_075140068.1 antitoxin Antitoxin
BTW26_RS06225 1258037..1258303 + 267 WP_075140069.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BTW26_RS06230 1258514..1259074 + 561 Protein_1194 site-specific integrase -
BTW26_RS06240 1259690..1261138 + 1449 WP_008841302.1 hypothetical protein -
BTW26_RS06245 1261371..1261754 - 384 WP_005917317.1 YxeA family protein -
BTW26_RS06250 1261983..1262231 - 249 WP_005917319.1 GlsB/YeaQ/YmgE family stress response membrane protein -
BTW26_RS06255 1262440..1263036 + 597 WP_008841306.1 DUF1211 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10577.06 Da        Isoelectric Point: 10.4916

>T70408 WP_075140069.1 NZ_CP018763:1258037-1258303 [Pediococcus acidilactici]
VSYRLEFTRDVQRSLRKMDKHQAKLIVRWLYQHVDGVEDPRSFGKGLTANRSGQWRYRIGNYRVIVEIEDNRMIVTAINI
GHRRDIYD

Download         Length: 267 bp

>T70408 NZ_CP018763:1258037-1258303 [Pediococcus acidilactici]
GTGAGTTATCGTCTTGAATTCACTCGTGACGTACAACGTTCACTCCGTAAAATGGATAAACATCAGGCAAAGTTAATTGT
TCGCTGGTTATATCAGCATGTAGATGGCGTTGAAGATCCACGTTCTTTTGGTAAAGGGTTAACCGCTAATCGTTCTGGAC
AATGGCGTTATCGCATTGGTAACTATCGAGTGATTGTAGAAATTGAAGACAACCGCATGATTGTTACTGCCATTAACATC
GGACACCGTCGAGATATATACGATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8942.98 Da        Isoelectric Point: 3.8737

>AT70408 WP_075140068.1 NZ_CP018763:1257810-1258040 [Pediococcus acidilactici]
MAMITVRVSDSEKEWLQYMADFYGITLSELLKNYSMEQLEDEYDQQVADLAHKRWLADNKQTVSMEDIIDEFGDLS

Download         Length: 231 bp

>AT70408 NZ_CP018763:1257810-1258040 [Pediococcus acidilactici]
ATGGCAATGATTACTGTAAGGGTTTCTGATTCGGAAAAAGAATGGCTCCAATATATGGCTGATTTTTACGGCATTACCTT
GTCTGAACTTTTAAAAAACTACTCTATGGAGCAATTAGAAGACGAGTACGACCAACAAGTAGCTGATTTAGCCCATAAAC
GCTGGCTTGCTGATAATAAGCAAACTGTATCTATGGAAGACATTATTGATGAATTCGGTGACCTATCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6HC80

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6HAU1

References