Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2608910..2609544 Replicon chromosome
Accession NZ_CP018762
Organism Microbacterium aurum strain KACC 15219

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BOH66_RS12800 Protein ID WP_076691405.1
Coordinates 2609164..2609544 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BOH66_RS12795 Protein ID WP_036285596.1
Coordinates 2608910..2609167 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOH66_RS12775 2604333..2604545 - 213 WP_198159195.1 WhiB family transcriptional regulator -
BOH66_RS12780 2604839..2606038 - 1200 WP_076691403.1 mannose-6-phosphate isomerase, class I -
BOH66_RS12785 2606120..2607526 + 1407 WP_076691404.1 O-antigen ligase family protein -
BOH66_RS12790 2607589..2608863 + 1275 WP_076692245.1 lipid A core--O-antigen ligase -
BOH66_RS12795 2608910..2609167 + 258 WP_036285596.1 ribbon-helix-helix domain-containing protein Antitoxin
BOH66_RS12800 2609164..2609544 + 381 WP_076691405.1 type II toxin-antitoxin system VapC family toxin Toxin
BOH66_RS12805 2609730..2610725 + 996 WP_076691406.1 glycosyltransferase family 2 protein -
BOH66_RS12810 2610923..2611258 + 336 WP_157127961.1 hypothetical protein -
BOH66_RS12815 2611349..2612866 + 1518 WP_076689818.1 IS1634 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13442.43 Da        Isoelectric Point: 6.8802

>T70406 WP_076691405.1 NZ_CP018762:2609164-2609544 [Microbacterium aurum]
VIIVDTDVLIAHLRGSTSAHAWLRRVAADEDLAISVATVAEIMGGMRSAERTAVRALLSALPAIPVSEVIAARAGDLQRE
FRRSHQGISLGDYLIAGTADTVGATVATLNTRHFPMFEGLQPPFRP

Download         Length: 381 bp

>T70406 NZ_CP018762:2609164-2609544 [Microbacterium aurum]
GTGATCATCGTCGACACCGACGTGCTCATCGCCCATCTCCGAGGCTCCACAAGCGCTCACGCGTGGCTCCGGCGTGTTGC
TGCCGATGAGGATCTCGCGATCAGCGTCGCGACCGTCGCGGAGATCATGGGCGGCATGCGCTCGGCTGAGCGCACAGCCG
TGCGCGCGCTGCTGTCAGCGCTGCCCGCGATACCGGTGAGCGAGGTCATCGCGGCGCGCGCTGGCGATCTGCAGCGGGAG
TTCCGACGCAGCCACCAAGGCATCTCCCTGGGCGACTATCTGATCGCAGGGACGGCAGACACGGTCGGAGCGACGGTGGC
GACACTGAACACCAGACACTTCCCGATGTTCGAGGGCCTCCAGCCGCCGTTTCGCCCCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9572.75 Da        Isoelectric Point: 6.3661

>AT70406 WP_036285596.1 NZ_CP018762:2608910-2609167 [Microbacterium aurum]
MRRTNIYLEERQTRALDRLADAEGTSRAEIIRRLIDRALDTGADRRNLLLAAIDASAGAAPELSVPARAGSEREQWLERL
RQDTV

Download         Length: 258 bp

>AT70406 NZ_CP018762:2608910-2609167 [Microbacterium aurum]
ATGCGGCGCACGAACATCTACCTGGAGGAGCGCCAGACCCGCGCTCTCGACAGGCTCGCCGACGCAGAGGGGACGTCGAG
GGCGGAGATCATCCGTCGACTCATCGACCGTGCGCTCGACACAGGCGCGGATCGGCGAAACCTTCTCCTCGCGGCCATCG
ACGCGTCGGCGGGTGCGGCCCCGGAGCTGTCTGTGCCCGCACGCGCAGGGAGCGAGCGCGAGCAGTGGCTCGAGCGACTG
CGACAGGACACCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References