Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 695670..696352 Replicon chromosome
Accession NZ_CP018762
Organism Microbacterium aurum strain KACC 15219

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BOH66_RS03475 Protein ID WP_076689330.1
Coordinates 695915..696352 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BOH66_RS03470 Protein ID WP_076689328.1
Coordinates 695670..695918 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOH66_RS03425 690841..691140 - 300 WP_076689311.1 putative addiction module antidote protein -
BOH66_RS03430 691124..691435 - 312 WP_076689313.1 type II toxin-antitoxin system RelE/ParE family toxin -
BOH66_RS03435 691893..692543 + 651 WP_076689315.1 hypothetical protein -
BOH66_RS03440 692696..693085 - 390 WP_076689317.1 hypothetical protein -
BOH66_RS03445 693133..693699 - 567 WP_157127866.1 hypothetical protein -
BOH66_RS03450 693767..693994 - 228 WP_076689322.1 RNA-binding S4 domain-containing protein -
BOH66_RS03455 693993..694295 + 303 WP_157127867.1 hypothetical protein -
BOH66_RS03460 694288..694740 - 453 Protein_686 GIY-YIG nuclease family protein -
BOH66_RS16875 694883..695020 - 138 WP_157127868.1 hypothetical protein -
BOH66_RS03465 695017..695352 - 336 WP_076689326.1 ATP-dependent DNA ligase -
BOH66_RS16880 695433..695576 - 144 Protein_689 gfo/Idh/MocA family oxidoreductase -
BOH66_RS03470 695670..695918 + 249 WP_076689328.1 hypothetical protein Antitoxin
BOH66_RS03475 695915..696352 + 438 WP_076689330.1 type II toxin-antitoxin system VapC family toxin Toxin
BOH66_RS03480 696493..697452 + 960 WP_084201911.1 MMPL family transporter -
BOH66_RS03485 697527..698006 + 480 WP_076689332.1 MarR family transcriptional regulator -
BOH66_RS03490 698148..699254 + 1107 WP_076689334.1 acyl-CoA desaturase -
BOH66_RS17280 699264..699419 - 156 WP_198159130.1 hypothetical protein -
BOH66_RS03495 699651..699923 + 273 WP_076689336.1 hypothetical protein -
BOH66_RS03500 699947..700273 + 327 WP_076689338.1 ATP-dependent DNA ligase -
BOH66_RS03505 700377..700673 + 297 WP_076692069.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15844.02 Da        Isoelectric Point: 5.9971

>T70404 WP_076689330.1 NZ_CP018762:695915-696352 [Microbacterium aurum]
VILLDTSVLVYAVGSDHPLQSRCRALIAAIGDGRVSATTTVEVLQEFAHVRARRRGRQDAAELTERFAALLAPLVPLEAE
DLERGMEVFRRHESLGAFDAVLAATAMRREHITGLVSADRAFADVARLRHLDPASSDFDAELGIR

Download         Length: 438 bp

>T70404 NZ_CP018762:695915-696352 [Microbacterium aurum]
GTGATCCTGCTCGACACCAGCGTCCTCGTCTACGCGGTCGGCTCGGACCACCCGCTGCAATCGCGGTGCCGCGCTCTCAT
CGCGGCGATCGGCGACGGCCGGGTGTCCGCGACCACGACGGTCGAGGTTCTGCAGGAGTTCGCGCACGTGCGGGCGCGCC
GGCGCGGCCGTCAGGATGCTGCGGAGCTGACGGAGCGCTTCGCAGCCCTGCTCGCCCCGCTCGTTCCCCTCGAGGCGGAG
GACCTCGAACGCGGCATGGAGGTGTTCCGCCGCCACGAGAGTCTCGGCGCGTTCGATGCCGTGCTCGCCGCAACAGCGAT
GCGGCGCGAGCACATCACGGGGCTGGTGTCCGCCGACCGCGCGTTCGCCGACGTTGCGCGCCTCCGTCACCTCGATCCCG
CGTCGAGCGACTTCGACGCCGAGCTCGGCATCCGCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8861.22 Da        Isoelectric Point: 8.7728

>AT70404 WP_076689328.1 NZ_CP018762:695670-695918 [Microbacterium aurum]
MSMKTERLQVLIDSVQRARLESTAAARGVSVAHLVRTAIDVVYPPDQTRRAAAAAAILQAPPMDVPEPAELRAELDTLRA
GR

Download         Length: 249 bp

>AT70404 NZ_CP018762:695670-695918 [Microbacterium aurum]
ATGAGCATGAAGACCGAGCGGCTGCAGGTGCTCATCGACAGCGTGCAGCGCGCGCGCCTCGAGTCGACCGCCGCCGCTCG
GGGCGTCTCAGTCGCCCACCTGGTTCGGACGGCGATCGACGTCGTCTATCCCCCTGATCAGACCCGGCGGGCCGCGGCGG
CCGCCGCGATCCTGCAGGCTCCGCCGATGGATGTGCCGGAACCCGCGGAGCTTCGTGCCGAGCTCGACACACTGCGAGCC
GGGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References