Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 3024453..3025123 Replicon chromosome
Accession NZ_CP018758
Organism Pseudomonas psychrotolerans strain PRS08-11306

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BJP27_RS13630 Protein ID WP_058788273.1
Coordinates 3024453..3024872 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BJP27_RS13635 Protein ID WP_074528954.1
Coordinates 3024869..3025123 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJP27_RS13610 3019666..3019998 + 333 WP_058761747.1 hypothetical protein -
BJP27_RS13615 3020039..3020992 - 954 WP_074528951.1 homoserine kinase -
BJP27_RS13620 3021053..3021346 - 294 WP_058761749.1 DUF2782 domain-containing protein -
BJP27_RS13625 3021457..3024204 + 2748 WP_074528952.1 DNA polymerase I -
BJP27_RS13630 3024453..3024872 - 420 WP_058788273.1 type II toxin-antitoxin system VapC family toxin Toxin
BJP27_RS13635 3024869..3025123 - 255 WP_074528954.1 Arc family DNA-binding protein Antitoxin
BJP27_RS13640 3025407..3026180 - 774 WP_167371483.1 electron transfer flavoprotein subunit beta -
BJP27_RS13645 3026197..3027432 - 1236 WP_074528958.1 electron transfer flavoprotein subunit alpha/FixB family protein -
BJP27_RS13650 3027602..3029593 - 1992 WP_074528959.1 dimethylglycine demethylation protein DgcB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(9-41)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15188.61 Da        Isoelectric Point: 7.7754

>T70392 WP_058788273.1 NZ_CP018758:c3024872-3024453 [Pseudomonas psychrotolerans]
MILLDTNVVSETMKPIPSPQVIAWLDRQAPATLYLSTITVAELQYGIACLPNSRRRDLLQQGVDALIRLYEGRILSFDLA
AACRYAELAAQARQRGLGFPLPDSYIGAIAAVSKFKIATRDEGPYLAAGLSIVNPWNTP

Download         Length: 420 bp

>T70392 NZ_CP018758:c3024872-3024453 [Pseudomonas psychrotolerans]
ATGATTCTGCTCGATACCAACGTCGTCTCCGAGACGATGAAGCCAATCCCCTCGCCCCAAGTCATCGCTTGGTTGGATCG
CCAAGCGCCAGCAACGCTGTACCTGTCGACGATCACCGTTGCCGAATTGCAATATGGTATTGCCTGCCTGCCCAATAGCC
GTCGTCGCGACCTATTGCAGCAAGGGGTAGACGCCTTGATCCGGCTCTATGAGGGCCGGATTCTGAGCTTCGATCTGGCT
GCTGCCTGTCGTTATGCCGAATTGGCCGCACAGGCTCGCCAGCGTGGTCTTGGCTTTCCCCTGCCTGATTCCTACATAGG
CGCGATTGCAGCGGTCAGCAAATTCAAGATCGCCACTCGAGACGAGGGGCCTTACCTCGCCGCGGGGCTCAGCATCGTCA
ATCCCTGGAACACACCCTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9455.84 Da        Isoelectric Point: 5.7152

>AT70392 WP_074528954.1 NZ_CP018758:c3025123-3024869 [Pseudomonas psychrotolerans]
MAQLTIRGLPEEVDRALRAQAARNGRSMEAEVRLILSQALILPTETPMGEAMAAIWRKPGITHEEQAFLEGTRDRRAHEP
MSFE

Download         Length: 255 bp

>AT70392 NZ_CP018758:c3025123-3024869 [Pseudomonas psychrotolerans]
ATGGCTCAATTGACCATCCGTGGACTACCGGAAGAAGTCGATCGCGCGCTTCGCGCCCAGGCAGCTCGCAACGGGCGGAG
CATGGAGGCTGAGGTCAGACTCATCCTTAGCCAAGCCTTGATCTTGCCGACCGAGACGCCGATGGGAGAGGCCATGGCCG
CTATCTGGCGCAAACCCGGGATCACTCACGAAGAGCAGGCTTTCCTCGAGGGGACGCGTGACCGGCGCGCCCATGAGCCG
ATGTCATTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References