70391

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2604029..2604666 Replicon chromosome
Accession NZ_CP018758
Organism Pseudomonas psychrotolerans strain PRS08-11306

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BJP27_RS11645 Protein ID WP_058760803.1
Coordinates 2604253..2604666 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A147GTJ9
Locus tag BJP27_RS11640 Protein ID WP_058760802.1
Coordinates 2604029..2604253 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJP27_RS11620 2599058..2600596 + 1539 WP_058772871.1 caspase family protein -
BJP27_RS11625 2600686..2601327 + 642 WP_058760799.1 oxidoreductase -
BJP27_RS11630 2601525..2602460 - 936 WP_058760800.1 LysR family transcriptional regulator -
BJP27_RS11635 2602587..2603963 + 1377 WP_074528739.1 L-serine ammonia-lyase -
BJP27_RS11640 2604029..2604253 + 225 WP_058760802.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BJP27_RS11645 2604253..2604666 + 414 WP_058760803.1 type II toxin-antitoxin system VapC family toxin Toxin
BJP27_RS11650 2604706..2605182 + 477 WP_074528741.1 YbaK/EbsC family protein -
BJP27_RS11655 2605444..2606844 + 1401 WP_074528742.1 PLP-dependent aminotransferase family protein -
BJP27_RS11660 2606841..2607137 - 297 WP_074528743.1 YceK/YidQ family lipoprotein -
BJP27_RS11665 2607130..2607762 - 633 WP_058760807.1 flavin prenyltransferase UbiX -
BJP27_RS11670 2607762..2609117 - 1356 WP_074528745.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-127)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15476.60 Da        Isoelectric Point: 6.3237

>T70391 WP_058760803.1 NZ_CP018758:2604253-2604666 [Pseudomonas psychrotolerans]
MPARYLLDTNICIYIAKHNPPQVRERFARHGRDELAMSVITWGELCHGAAKSQQPERTQAILEQLRQQIAVLELDADCAE
HYGAIRAELERQGKIIGNNDLWIAAHARAQGLILVSNNLREFSRVDGLACENWTEAC

Download         Length: 414 bp

>T70391 NZ_CP018758:2604253-2604666 [Pseudomonas psychrotolerans]
ATGCCTGCCCGCTATCTGCTGGACACCAACATCTGCATCTATATCGCCAAGCATAATCCACCGCAGGTCCGCGAACGCTT
CGCCCGACACGGGCGCGATGAACTGGCGATGTCTGTGATTACTTGGGGCGAACTCTGTCATGGTGCTGCCAAGAGTCAGC
AGCCCGAACGCACGCAAGCGATCCTGGAGCAGCTGCGACAGCAGATCGCCGTGCTCGAGCTGGATGCGGATTGCGCCGAA
CACTATGGCGCCATTCGTGCCGAGCTGGAGCGTCAGGGCAAGATCATCGGCAATAACGATCTGTGGATCGCCGCCCATGC
CCGCGCCCAAGGGCTGATCCTGGTAAGCAACAACCTGCGCGAATTCAGCAGGGTTGATGGCCTGGCCTGCGAAAACTGGA
CAGAAGCCTGCTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8533.71 Da        Isoelectric Point: 5.1617

>AT70391 WP_058760802.1 NZ_CP018758:2604029-2604253 [Pseudomonas psychrotolerans]
MAEARVFKSGNSQALRLPKEFRFESDRVEIFRRGDEIVLRELRPSAVDIFDTLAALSLSTLERKDSPPQVREEL

Download         Length: 225 bp

>AT70391 NZ_CP018758:2604029-2604253 [Pseudomonas psychrotolerans]
ATGGCCGAAGCCCGAGTTTTTAAATCCGGTAACAGTCAGGCCTTACGCCTACCAAAGGAATTTCGTTTCGAATCGGATCG
GGTAGAAATCTTCCGCCGCGGCGACGAGATCGTCCTGCGAGAGTTGCGGCCCAGCGCAGTCGACATCTTCGACACCCTGG
CCGCGCTGTCGCTGTCGACGTTGGAACGGAAAGACAGTCCACCGCAGGTACGGGAAGAGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A147GTJ9

References