Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4800018..4800534 Replicon chromosome
Accession NZ_CP018686
Organism Klebsiella pneumoniae strain Kp_Goe_149473

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag BB750_RS24685 Protein ID WP_009486548.1
Coordinates 4800018..4800302 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag BB750_RS24690 Protein ID WP_002886901.1
Coordinates 4800292..4800534 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB750_RS24655 4795435..4795743 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
BB750_RS32810 4795828..4796001 + 174 WP_032433782.1 hypothetical protein -
BB750_RS24665 4796004..4796747 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
BB750_RS24675 4797104..4799242 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
BB750_RS24680 4799550..4800014 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
BB750_RS24685 4800018..4800302 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BB750_RS24690 4800292..4800534 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BB750_RS24695 4800612..4802522 - 1911 WP_009486549.1 BglG family transcription antiterminator -
BB750_RS24700 4802545..4803699 - 1155 WP_002886900.1 lactonase family protein -
BB750_RS24705 4803766..4804506 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T70222 WP_009486548.1 NZ_CP018686:c4800302-4800018 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T70222 NZ_CP018686:c4800302-4800018 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT70222 WP_002886901.1 NZ_CP018686:c4800534-4800292 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT70222 NZ_CP018686:c4800534-4800292 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References