Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 5163..5679 Replicon plasmid p3
Accession NZ_CP018684
Organism Vibrio harveyi strain QT520

Toxin (Protein)


Gene name relB Uniprot ID A0A8B3DGM6
Locus tag BG259_RS28365 Protein ID WP_017191054.1
Coordinates 5163..5432 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A8B3E3Y5
Locus tag BG259_RS28370 Protein ID WP_017191055.1
Coordinates 5425..5679 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG259_RS28330 338..502 - 165 Protein_0 type II toxin-antitoxin system HicB family antitoxin -
BG259_RS28335 886..1713 + 828 WP_074052118.1 hypothetical protein -
BG259_RS28340 2341..3108 + 768 WP_017191050.1 ParA family protein -
BG259_RS28345 3118..3414 + 297 WP_017191051.1 hypothetical protein -
BG259_RS28350 3624..3824 - 201 WP_017191052.1 hypothetical protein -
BG259_RS28355 4085..4646 + 562 Protein_5 AAA family ATPase -
BG259_RS28360 4656..4975 + 320 Protein_6 hypothetical protein -
BG259_RS28365 5163..5432 - 270 WP_017191054.1 Txe/YoeB family addiction module toxin Toxin
BG259_RS28370 5425..5679 - 255 WP_017191055.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BG259_RS28375 5831..6193 - 363 Protein_9 hypothetical protein -
BG259_RS28380 6197..7389 + 1193 Protein_10 IS91 family transposase -
BG259_RS28385 7588..8316 - 729 WP_074052119.1 hypothetical protein -
BG259_RS28390 8775..9134 - 360 WP_017191058.1 hypothetical protein -
BG259_RS28395 9362..9634 + 273 WP_017420534.1 DUF1778 domain-containing protein -
BG259_RS28400 9631..10128 + 498 WP_017191060.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..59857 59857


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10588.92 Da        Isoelectric Point: 9.4082

>T70204 WP_017191054.1 NZ_CP018684:c5432-5163 [Vibrio harveyi]
MSSSQRLLSWTNDAWGDYLYWQTQDKKTLKRINKLINDTKRSPFEGIGKPEQLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Download         Length: 270 bp

>T70204 NZ_CP018684:c5432-5163 [Vibrio harveyi]
ATGAGTAGTAGTCAACGTTTATTGTCGTGGACTAATGACGCTTGGGGTGACTATCTGTATTGGCAAACTCAAGACAAGAA
AACACTCAAACGCATCAACAAACTCATCAATGATACCAAGCGCTCCCCATTTGAGGGCATCGGTAAACCAGAGCAGTTAA
AAGAGAACTTGTCTGGTTTTTGGTCTCGTCGTATTGATGACACTAACAGACTTGTTTATGCAGTTGATGATCAAGCGATA
ACGATAATTTCGTGTCGCTACCACTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9453.60 Da        Isoelectric Point: 4.7483

>AT70204 WP_017191055.1 NZ_CP018684:c5679-5425 [Vibrio harveyi]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNVEHLNRSIAQYRAGKTTAQE
LIDE

Download         Length: 255 bp

>AT70204 NZ_CP018684:c5679-5425 [Vibrio harveyi]
ATGAGAATTGTATCTTTTACTGAAGCTAGAAACGGCCTTAAAGCTGTTTTAGACGGTGTAGTTAATGACGCAGACACAAC
AGTCATTACACGTCGTGACTCTGAGGATGCTGTGGTTATGTCTTTAGATTACTACAATAGCCTTATGGAGACAGTTCACT
TACTACGCTCTCCTCAAAACGTTGAACACTTAAACCGTTCTATAGCACAGTACCGTGCAGGTAAAACAACAGCACAAGAG
TTAATTGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3DGM6

Antitoxin

Source ID Structure
AlphaFold DB A0A8B3E3Y5

References