Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1265115..1265674 Replicon chromosome
Accession NZ_CP018680
Organism Vibrio harveyi strain QT520

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag BG259_RS06005 Protein ID WP_038882476.1
Coordinates 1265396..1265674 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag BG259_RS06000 Protein ID WP_005398409.1
Coordinates 1265115..1265399 (+) Length 95 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG259_RS05935 1260687..1260779 - 93 WP_074050602.1 DUF3265 domain-containing protein -
BG259_RS05940 1260794..1261243 - 450 WP_074050603.1 C-GCAxxG-C-C family protein -
BG259_RS05945 1261275..1261424 - 150 WP_074050604.1 DUF3265 domain-containing protein -
BG259_RS05950 1261393..1261953 - 561 WP_074050605.1 hypothetical protein -
BG259_RS05955 1262040..1262162 - 123 WP_074050606.1 DUF3265 domain-containing protein -
BG259_RS05960 1262159..1262659 - 501 WP_074050607.1 hypothetical protein -
BG259_RS05965 1262703..1262819 - 117 WP_074050608.1 DUF3265 domain-containing protein -
BG259_RS05970 1262810..1263262 - 453 WP_074051167.1 hypothetical protein -
BG259_RS05975 1263714..1263824 - 111 WP_072615051.1 DUF3265 domain-containing protein -
BG259_RS05980 1263821..1264423 - 603 WP_074050609.1 hypothetical protein -
BG259_RS28685 1264452..1264646 - 195 WP_079400279.1 DUF3265 domain-containing protein -
BG259_RS05990 1264568..1264927 - 360 WP_074050610.1 hypothetical protein -
BG259_RS05995 1264937..1265038 - 102 Protein_1161 DUF3265 domain-containing protein -
BG259_RS06000 1265115..1265399 + 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BG259_RS06005 1265396..1265674 + 279 WP_038882476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BG259_RS06010 1266251..1266382 - 132 WP_074050611.1 DUF3265 domain-containing protein -
BG259_RS06015 1266871..1266975 - 105 WP_074050612.1 DUF3265 domain-containing protein -
BG259_RS06020 1266960..1267280 - 321 WP_074050613.1 hypothetical protein -
BG259_RS06025 1267329..1267445 - 117 WP_074050614.1 DUF3265 domain-containing protein -
BG259_RS06030 1267436..1267945 - 510 WP_045390294.1 ClbS/DfsB family four-helix bundle protein -
BG259_RS06035 1268082..1268765 - 684 WP_074050615.1 hypothetical protein -
BG259_RS06040 1268793..1268903 - 111 WP_074050616.1 DUF3265 domain-containing protein -
BG259_RS06045 1268909..1269544 - 636 WP_042764315.1 hypothetical protein -
BG259_RS06050 1269654..1270340 - 687 WP_074050617.1 hypothetical protein -
BG259_RS06055 1270364..1270480 - 117 WP_155771795.1 DUF3265 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1207992..1282830 74838
- inside Integron - - 1209479..1282830 73351


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10905.60 Da        Isoelectric Point: 4.3430

>T70203 WP_038882476.1 NZ_CP018680:1265396-1265674 [Vibrio harveyi]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGLQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T70203 NZ_CP018680:1265396-1265674 [Vibrio harveyi]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCGCTAATGGGTCTGCAAAGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTCTCTTACTGGGTCGAGGGCGATATCATCAGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT70203 WP_005398409.1 NZ_CP018680:1265115-1265399 [Vibrio harveyi]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT70203 NZ_CP018680:1265115-1265399 [Vibrio harveyi]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCTTAGCTCAACAAATGGCTGAGAGCCAAGGTCGAAC
TCTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAACACCAAACTGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References