Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1244168..1244696 Replicon chromosome
Accession NZ_CP018680
Organism Vibrio harveyi strain QT520

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag BG259_RS05765 Protein ID WP_005377002.1
Coordinates 1244406..1244696 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag BG259_RS05760 Protein ID WP_005377003.1
Coordinates 1244168..1244416 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG259_RS05715 1239191..1239283 - 93 WP_074050578.1 DUF3265 domain-containing protein -
BG259_RS28680 1239305..1239880 - 576 WP_081384157.1 hypothetical protein -
BG259_RS05720 1240018..1240890 - 873 WP_025816682.1 putative phage abortive infection protein -
BG259_RS28825 1240930..1241019 - 90 WP_104027912.1 DUF3265 domain-containing protein -
BG259_RS05725 1241041..1241409 - 369 WP_155771767.1 RDD family protein -
BG259_RS05730 1241388..1241489 - 102 WP_074051162.1 DUF3265 domain-containing protein -
BG259_RS05735 1241480..1242646 - 1167 WP_029811084.1 DUF4062 domain-containing protein -
BG259_RS05740 1242689..1242781 - 93 Protein_1109 DUF3265 domain-containing protein -
BG259_RS05745 1242796..1243428 - 633 WP_045604826.1 hypothetical protein -
BG259_RS05750 1243465..1243611 - 147 WP_074051163.1 DUF3265 domain-containing protein -
BG259_RS05755 1243572..1243961 - 390 WP_074050579.1 DUF4345 domain-containing protein -
BG259_RS05760 1244168..1244416 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BG259_RS05765 1244406..1244696 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BG259_RS05770 1244834..1245907 - 1074 WP_074050580.1 hypothetical protein -
BG259_RS05775 1246580..1246722 - 143 Protein_1116 DUF3265 domain-containing protein -
BG259_RS05780 1246686..1247099 - 414 WP_074050581.1 hypothetical protein -
BG259_RS05785 1247092..1248027 - 936 WP_074050582.1 AAA family ATPase -
BG259_RS28830 1248293..1248538 - 246 WP_074050583.1 helix-turn-helix domain-containing protein -
BG259_RS05795 1248740..1248931 + 192 WP_074050584.1 hypothetical protein -
BG259_RS28835 1248934..1249110 + 177 WP_155771768.1 hypothetical protein -
BG259_RS05800 1249200..1249328 - 129 WP_074051164.1 DUF3265 domain-containing protein -
BG259_RS05805 1249283..1249633 - 351 WP_005537156.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1207992..1282830 74838
- inside Integron - - 1209479..1282830 73351


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T70202 WP_005377002.1 NZ_CP018680:1244406-1244696 [Vibrio harveyi]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T70202 NZ_CP018680:1244406-1244696 [Vibrio harveyi]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAATTGTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTGATCATTGTAACCGTCCTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT70202 WP_005377003.1 NZ_CP018680:1244168-1244416 [Vibrio harveyi]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT70202 NZ_CP018680:1244168-1244416 [Vibrio harveyi]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTAGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTCGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References