Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1221741..1222288 Replicon chromosome
Accession NZ_CP018680
Organism Vibrio harveyi strain QT520

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag BG259_RS05510 Protein ID WP_015296906.1
Coordinates 1221741..1222043 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7Y3ZEQ4
Locus tag BG259_RS05515 Protein ID WP_015296907.1
Coordinates 1222031..1222288 (-) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG259_RS05455 1217768..1217970 - 203 Protein_1055 hypothetical protein -
BG259_RS05460 1217979..1218380 - 402 WP_074050547.1 type II toxin-antitoxin system YafO family toxin -
BG259_RS28805 1218386..1218559 - 174 WP_155771766.1 hypothetical protein -
BG259_RS05465 1218747..1219040 - 294 WP_074050548.1 hypothetical protein -
BG259_RS05475 1219218..1219862 - 645 WP_074050549.1 peptidase E -
BG259_RS05480 1219904..1220035 - 132 WP_074050550.1 DUF3265 domain-containing protein -
BG259_RS05485 1220538..1220957 - 420 WP_005536771.1 hypothetical protein -
BG259_RS05490 1220993..1221124 - 132 WP_074050551.1 DUF3265 domain-containing protein -
BG259_RS28810 1221211..1221513 + 303 WP_029790594.1 hypothetical protein -
BG259_RS05505 1221613..1221705 - 93 WP_074050554.1 DUF3265 domain-containing protein -
BG259_RS05510 1221741..1222043 - 303 WP_015296906.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BG259_RS05515 1222031..1222288 - 258 WP_015296907.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BG259_RS05520 1222370..1222459 - 90 WP_072829120.1 DUF3265 domain-containing protein -
BG259_RS05535 1222980..1223186 - 207 WP_081384156.1 DUF3265 domain-containing protein -
BG259_RS28815 1223095..1223673 - 579 WP_074050557.1 hypothetical protein -
BG259_RS05545 1223700..1223834 - 135 WP_074050558.1 DUF3265 domain-containing protein -
BG259_RS05550 1223807..1224301 - 495 WP_074050559.1 DUF695 domain-containing protein -
BG259_RS05555 1224330..1224476 - 147 WP_074051159.1 DUF3265 domain-containing protein -
BG259_RS05560 1224437..1224790 - 354 WP_074050560.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
BG259_RS05565 1224819..1224950 - 132 WP_017420680.1 DUF3265 domain-containing protein -
BG259_RS05575 1225439..1225573 - 135 WP_074050562.1 DUF3265 domain-containing protein -
BG259_RS05580 1225546..1226319 - 774 WP_074050563.1 NERD domain-containing protein -
BG259_RS05585 1226457..1227104 - 648 WP_074050564.1 HAD family phosphatase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1207992..1282830 74838
- inside Integron - - 1209479..1282830 73351


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 101 a.a.        Molecular weight: 11727.61 Da        Isoelectric Point: 4.8838

>T70201 WP_015296906.1 NZ_CP018680:c1222043-1221741 [Vibrio harveyi]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDDDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T70201 NZ_CP018680:c1222043-1221741 [Vibrio harveyi]
ATGGCTGAAATAATCTGGACTGAACCAGCTTTATCTGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGATGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAACAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9638.16 Da        Isoelectric Point: 6.7269

>AT70201 WP_015296907.1 NZ_CP018680:c1222288-1222031 [Vibrio harveyi]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKMVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT70201 NZ_CP018680:c1222288-1222031 [Vibrio harveyi]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGATACCAAAGAGCCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCTTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGACGGTAAAATGGTAAGCCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A7Y3ZEQ4

References