Detailed information of TA system TA070200

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 2556684..2557194
• Replicon: chromosome
• Accession: NZ_CP018677
• Organism: Acinetobacter baumannii strain LAC4

Toxin (Protein)

• Gene name: relB
• Uniprot ID: A0A4Q4HKU6
• Locus tag: BBX32_RS12410
• Protein ID: WP_000824257.1
• Coordinates: 2556931..2557194 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7S8XU62
• Locus tag: BBX32_RS12405
• Protein ID: WP_001165438.1
• Coordinates: 2556684..2556947 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BBX32_RS12385	2552576..2553508	+	933	WP_001043692.1	IS5-like element ISAba13 family transposase	-
BBX32_RS12390	2553819..2555042	+	1224	WP_000261481.1	inovirus-type Gp2 protein	-
BBX32_RS12395	2555039..2556067	+	1029	WP_001101792.1	hypothetical protein	-
BBX32_RS12400	2556064..2556330	+	267	WP_000570798.1	AlpA family phage regulatory protein	-
BBX32_RS12405	2556684..2556947	+	264	WP_001165438.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
BBX32_RS12410	2556931..2557194	+	264	WP_000824257.1	Txe/YoeB family addiction module toxin	Toxin
BBX32_RS12415	2557563..2557946	+	384	WP_001055585.1	IS66 family insertion sequence hypothetical protein	-
BBX32_RS12420	2557943..2558278	+	336	WP_000618091.1	IS66 family insertion sequence element accessory protein TnpB	-
BBX32_RS12425	2558353..2559936	+	1584	WP_005080579.1	IS66-like element ISAba25 family transposase	-
BBX32_RS12430	2560009..2561196	-	1188	WP_002036368.1	DUF4268 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2534301..2559936	25635
	-	inside	IScluster/Tn	-	-	2552576..2559936	7360

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10337.91 Da
• Isoelectric Point: 9.0098

>T70200 WP_000824257.1 NZ_CP018677:2556931-2557194 [Acinetobacter baumannii]
MKRKTSFTPTAWEDYVYWQNQDKKTLKRINTLIKECLRTPFDGIGKPEPLLGDLAGLWSRRIDEKNRLVYEVTDVAITII
SCRYHYE

Nucleotide

• Length: 264 bp

>T70200 NZ_CP018677:2556931-2557194 [Acinetobacter baumannii]
ATGAAACGGAAGACTAGTTTTACTCCAACAGCTTGGGAGGATTATGTATATTGGCAAAACCAAGACAAAAAGACTCTTAA
GCGCATCAATACATTAATCAAAGAGTGTCTTCGTACCCCCTTTGATGGTATTGGCAAGCCTGAACCATTACTCGGTGATT
TAGCAGGTTTGTGGAGCAGACGAATAGATGAAAAAAATAGATTAGTCTATGAAGTAACTGATGTAGCGATAACTATCATT
TCTTGTCGTTATCACTACGAATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9796.01 Da
• Isoelectric Point: 4.6112

>AT70200 WP_001165438.1 NZ_CP018677:2556684-2556947 [Acinetobacter baumannii]
MQIFTYTDARNNLKTVLDRVIDDSDVAVITRKEGQHAVVMGQDYYNSIMETLHLMSSPSNAAHLAKSIAELRASKAIERE
LLDETED

Nucleotide

• Length: 264 bp

>AT70200 NZ_CP018677:2556684-2556947 [Acinetobacter baumannii]
ATGCAAATTTTCACTTATACCGATGCTCGCAATAATCTGAAAACGGTTTTAGACCGTGTCATTGATGATTCAGATGTTGC
AGTAATTACGAGAAAAGAAGGTCAACATGCAGTTGTAATGGGACAAGACTATTACAATAGTATAATGGAGACATTGCACC
TCATGTCTTCTCCAAGTAATGCAGCACACCTAGCGAAATCAATTGCAGAATTACGGGCATCTAAAGCAATCGAAAGAGAA
CTTTTAGATGAAACGGAAGACTAG

Structures

Toxin

• AlphaFold DB: A0A4Q4HKU6