Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 2185227..2185930 Replicon chromosome
Accession NZ_CP018671
Organism Klebsiella pneumoniae strain CAV1042

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag AGE78_RS13375 Protein ID WP_071557095.1
Coordinates 2185227..2185568 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag AGE78_RS13380 Protein ID WP_009309674.1
Coordinates 2185589..2185930 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AGE78_RS13355 2180454..2182199 + 1746 WP_004149864.1 DNA primase -
AGE78_RS13360 2182418..2184259 + 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -
AGE78_RS13365 2184359..2184865 - 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
AGE78_RS13375 2185227..2185568 - 342 WP_071557095.1 TA system toxin CbtA family protein Toxin
AGE78_RS13380 2185589..2185930 - 342 WP_009309674.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AGE78_RS13385 2185941..2186483 - 543 WP_009309673.1 DNA repair protein RadC -
AGE78_RS13390 2186496..2186938 - 443 Protein_2114 antirestriction protein -
AGE78_RS13395 2186969..2187790 - 822 WP_009309670.1 DUF945 domain-containing protein -
AGE78_RS13400 2187988..2188851 - 864 WP_009309669.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12860.89 Da        Isoelectric Point: 9.6542

>T70169 WP_071557095.1 NZ_CP018671:c2185568-2185227 [Klebsiella pneumoniae]
MKTLPATISRAAKPCLSPVAAWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVDKYELVRIDRRGF
NWQEQSPYLRAVDILRARQAIGLLRRSRNNAVL

Download         Length: 342 bp

>T70169 NZ_CP018671:c2185568-2185227 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCTACAATTTCGCGTGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGCCTGGCAAATGTTACTGAC
ACGCCTACTGGAACAGCACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATTG
ATGCCGGGATTACCCTGGCCGATGCAGTCAACTTCCTGGTGGATAAGTACGAACTGGTTCGTATCGATCGCAGGGGGTTT
AACTGGCAGGAGCAATCCCCTTATCTTCGGGCGGTAGATATCCTGCGAGCACGACAAGCAATTGGCTTGTTGCGACGGAG
CCGTAATAACGCTGTATTGTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12735.41 Da        Isoelectric Point: 6.3157

>AT70169 WP_009309674.1 NZ_CP018671:c2185930-2185589 [Klebsiella pneumoniae]
MKSTESENDLFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGAFSNAESLKLDEVFPRFISQMESMLTIGEMNPHH
AHCVTLYHNGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 342 bp

>AT70169 NZ_CP018671:c2185930-2185589 [Klebsiella pneumoniae]
ATGAAATCTACTGAGTCAGAGAACGATTTATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGACTTCACTATCTGGCTGACCGGGCCAGCATTACCGGTGCATTCAGTAACGCAGAATCTT
TGAAGTTGGATGAAGTATTCCCACGTTTTATCAGCCAGATGGAATCGATGTTGACCATTGGTGAAATGAATCCTCACCAT
GCCCACTGCGTCACCCTATACCACAACGGTTTCACCTGCGAAGCCGATACTCTTGGCAGTTGCGGCTACGTATACATCGC
CGTTTACCCCACTCAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References