Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2036465..2037122 Replicon chromosome
Accession NZ_CP018671
Organism Klebsiella pneumoniae strain CAV1042

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag AGE78_RS12570 Protein ID WP_002916310.1
Coordinates 2036465..2036875 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag AGE78_RS12575 Protein ID WP_002916312.1
Coordinates 2036856..2037122 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AGE78_RS12550 2032465..2034198 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
AGE78_RS12555 2034204..2034917 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AGE78_RS12560 2034940..2035836 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
AGE78_RS12565 2035937..2036458 + 522 WP_002916308.1 flavodoxin FldB -
AGE78_RS12570 2036465..2036875 - 411 WP_002916310.1 protein YgfX Toxin
AGE78_RS12575 2036856..2037122 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
AGE78_RS12580 2037368..2038351 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
AGE78_RS12585 2038502..2039161 - 660 WP_002916317.1 hemolysin III family protein -
AGE78_RS12590 2039325..2039636 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
AGE78_RS12595 2039686..2040414 + 729 WP_040153267.1 MurR/RpiR family transcriptional regulator -
AGE78_RS12600 2040533..2041966 + 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T70167 WP_002916310.1 NZ_CP018671:c2036875-2036465 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T70167 NZ_CP018671:c2036875-2036465 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT70167 WP_002916312.1 NZ_CP018671:c2037122-2036856 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT70167 NZ_CP018671:c2037122-2036856 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References