70151

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3473332..3474968 Replicon chromosome
Accession NZ_CP018664
Organism Acinetobacter baumannii strain ATCC 17978

Toxin (Protein)


Gene name hipA Uniprot ID A0A1E3M7C1
Locus tag AUO97_RS16640 Protein ID WP_000737056.1
Coordinates 3473637..3474968 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag AUO97_RS16635 Protein ID WP_001101308.1
Coordinates 3473332..3473640 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AUO97_RS16605 (AUO97_16605) 3468896..3469414 - 519 WP_000651611.1 GNAT family N-acetyltransferase -
AUO97_RS16610 (AUO97_16610) 3469562..3470077 - 516 WP_000914805.1 hypothetical protein -
AUO97_RS16615 (AUO97_16615) 3470119..3471201 - 1083 WP_001095788.1 ImmA/IrrE family metallo-endopeptidase -
AUO97_RS16620 (AUO97_16620) 3471219..3471839 - 621 WP_000658761.1 hypothetical protein -
AUO97_RS16625 (AUO97_16625) 3472055..3472606 - 552 WP_049594830.1 TetR/AcrR family transcriptional regulator -
AUO97_RS16635 (AUO97_16635) 3473332..3473640 - 309 WP_001101308.1 helix-turn-helix domain-containing protein Antitoxin
AUO97_RS16640 (AUO97_16640) 3473637..3474968 - 1332 WP_000737056.1 type II toxin-antitoxin system HipA family toxin Toxin
AUO97_RS16645 (AUO97_16645) 3475264..3475704 + 441 WP_000193135.1 HD domain-containing protein -
AUO97_RS16650 (AUO97_16650) 3475739..3476383 - 645 WP_000817301.1 hypothetical protein -
AUO97_RS16655 (AUO97_16655) 3476395..3477366 - 972 WP_109104914.1 acid phosphatase -
AUO97_RS16660 (AUO97_16660) 3477493..3478653 - 1161 WP_001044492.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51189.16 Da        Isoelectric Point: 4.7456

>T70151 WP_000737056.1 NZ_CP018664:c3474968-3473637 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNNRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

>T70151 NZ_CP018664:c3474968-3473637 [Acinetobacter baumannii]
ATGAAAAAATTAACGATACAAGCTTTACTAAATAAAAACTGGATAGATATAGCAGAGCTAAAACTGTTAGAACCTAAGTT
GGGTTCGGCTAGCGCCAGTGAACTAGAATATGAATTGGATTATGCAATTCAATATTTAGACAGACGAGATGAGCACGCCT
GTAGTTTATCACTTCCTGTACAAATTCTTATCAAACACGAATCGGATACATGGTTTGGCTTTTTAGATGATATTGTTCCA
TCTGGCGCTGCACGCCGTTATTGGGTGAATTATCTAGATTTACAACGCTTAACCTATGCGGAACAAGAAAGTATTCTATT
AGAAAAAGGTGGGATGGCACCTGTTGGTAATTTACGAATTAAAGAAGCATTGCCTCCACTAAACCCAGAGTCAACCTTGC
ACTTACGTTATTTTAGTAAGGAAGATGTGGCTGAGCGTAATATTGATTTTCTGGAATATGCTCAACAAATGGGAGCTATT
AGTGGTGGTGCAACTGGTGCAGGCGGTGAAGCTCCCAAGTTGCTTATTCGTGTTTCACCGGAACAAAAAGTCTGGATTGA
CACCTACCAAGAACAATTTGATCAGCCAGATCAGCATTATTTAGTTAAATTTCCGCGAAATAATCGTAGCGAGATTGATT
GCGATATTCTCAGAGCTGAATATTATTACTATCAAATACTCAATGAGTTAGGTTTCAATACGATAGAGACGACTCAAATG
CAGCTTATTGAAGGTACAAAATATCCGTCATTGTGGCTTCCAAGATTCGATACAGAATGGTGTGATCAATATTGGCACCG
CTATGGTCTAGAGTCTGTGTATTCTGTACTAAATAAGTCTTCTGGTAGTCATCTTAATCATTTCGAAGTCATTGAAGATC
TATGTAGATTACTCACAAGCATTGACTCAGATTTTGATGTACCACAATTTATTTGTGAGTGGTTACAACGCGACTTACTC
AATATCATTTTTGGCAATTCAGATAACCACGGTCGGAATACATCGTTTATAAAAAAATCTGGAAAAATTTATCTTTCGCC
TATTTATGACTTTGCACCTATGAAAGCCGATCCAGAAGTTGTGACCAGATCGACGACTTGGGGAAGTCCGTATGAGGAAG
GAGGTGAATACCGGTGGGCACAAATTACACAAAAACTTGCTCCTTGGTGCGATCCCGATTTATCTCTAGCAACATTAAGG
ACTTTGGCGAATAACCTGCTTGGCTTAAAGCAACGATTAGTTGATAAAGGTGTACCAAAACAAATTATTGAAATGCCAGC
GCTGTCATTTGATTACATAGAAGCTAAATTGAAAAGATGGGAACTGCTATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11626.55 Da        Isoelectric Point: 9.9701

>AT70151 WP_001101308.1 NZ_CP018664:c3473640-3473332 [Acinetobacter baumannii]
MNVKNQPQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Download         Length: 309 bp

>AT70151 NZ_CP018664:c3473640-3473332 [Acinetobacter baumannii]
ATGAATGTAAAAAATCAACCCCAAGACCGTCAGCAGATTCTTATAGATTTATATAAACAATATTTGTTGAGTGAGATTAC
TTTGGGGCAATTGCTATCGTATTTACGCAAAAATGTGTTGGGTTTATCGCAAGAACAATATGCTAATTTGGTGGGTATAA
GCCGTCGGACTTTAACGGACATTGAGCAGGATAAAGGTAAACTCACTCAGTCTGTGTTAGATAAAGTGTTTAAACCACTT
GGTTTAAAAGCAGGGCTTGTACCTACGCATGAACATATTGTTAGCAAAATTATAAAGCCAAACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3M7C1

Antitoxin

Source ID Structure

References