Detailed information of TA system TA070149

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 9216..9741
• Replicon: plasmid pSE95-0621-2
• Accession: NZ_CP018663
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain 95-0621

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: BTN69_RS24250
• Protein ID: WP_001159863.1
• Coordinates: 9216..9521 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: BTN69_RS24255
• Protein ID: WP_000813641.1
• Coordinates: 9523..9741 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTN69_RS24210	4595..5155	-	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-
BTN69_RS24220	5875..6360	-	486	WP_000905606.1	membrane protein	-
BTN69_RS24225	6354..6863	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
BTN69_RS24230	6867..7580	-	714	WP_000545756.1	EAL domain-containing protein	-
BTN69_RS24235	7589..8371	-	783	WP_000082169.1	site-specific integrase	-
BTN69_RS24240	8406..8927	-	522	WP_000198608.1	hypothetical protein	-
BTN69_RS24245	8924..9214	-	291	WP_001266176.1	hypothetical protein	-
BTN69_RS24250	9216..9521	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
BTN69_RS24255	9523..9741	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
BTN69_RS24260	10417..10938	+	522	WP_077681952.1	hypothetical protein	-
BTN69_RS24860	10982..11410	-	429	Protein_15	hypothetical protein	-
BTN69_RS24270	11422..11717	+	296	Protein_16	cytoplasmic protein	-
BTN69_RS24275	12211..13200	+	990	WP_000461382.1	RepB family plasmid replication initiator protein	-
BTN69_RS24280	13527..13688	-	162	WP_015059604.1	hypothetical protein	-
BTN69_RS24285	13741..14127	-	387	WP_000751876.1	YgiW/YdeI family stress tolerance OB fold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..59356	59356

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T70149 WP_001159863.1 NZ_CP018663:c9521-9216 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T70149 NZ_CP018663:c9521-9216 [Salmonella enterica subsp. enterica serovar Enteritidis]
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Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT70149 WP_000813641.1 NZ_CP018663:c9741-9523 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT70149 NZ_CP018663:c9741-9523 [Salmonella enterica subsp. enterica serovar Enteritidis]
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Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6