Detailed information of TA system TA070148

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 40566..41088
• Replicon: plasmid pSE95-0621-1
• Accession: NZ_CP018662
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain 95-0621

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G3CAN5
• Locus tag: BTN69_RS24115
• Protein ID: WP_000220560.1
• Coordinates: 40566..40847 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: BTN69_RS24120
• Protein ID: WP_000121743.1
• Coordinates: 40837..41088 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTN69_RS24070	36411..37577	-	1167	WP_001505431.1	relaxase/mobilization nuclease domain-containing protein	-
BTN69_RS24075	37580..38125	-	546	WP_000757693.1	hypothetical protein	-
BTN69_RS24850	38120..38194	-	75	Protein_39	DNA distortion polypeptide 3	-
BTN69_RS24080	38451..38723	-	273	WP_000160399.1	hypothetical protein	-
BTN69_RS24855	38736..38885	-	150	WP_000003877.1	hypothetical protein	-
BTN69_RS24090	38955..39134	-	180	WP_021526659.1	hypothetical protein	-
BTN69_RS24095	39177..39506	-	330	WP_000866654.1	hypothetical protein	-
BTN69_RS24100	39599..39814	-	216	WP_001180117.1	hypothetical protein	-
BTN69_RS24105	39804..40049	-	246	WP_000356542.1	hypothetical protein	-
BTN69_RS24110	40097..40420	-	324	WP_001181906.1	hypothetical protein	-
BTN69_RS24115	40566..40847	-	282	WP_000220560.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BTN69_RS24120	40837..41088	-	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
BTN69_RS24130	42321..43160	+	840	WP_021526660.1	replication initiation protein	-
BTN69_RS24135	43181..44023	+	843	WP_000435061.1	replication initiation protein	-
BTN69_RS24140	44027..44470	+	444	WP_001074380.1	hypothetical protein	-
BTN69_RS24145	44541..44966	+	426	WP_000202954.1	hypothetical protein	-
BTN69_RS24150	44963..45940	-	978	WP_001269912.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..51980	51980

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 13852.62 Da
• Isoelectric Point: 5.5500

>T70148 WP_000220560.1 NZ_CP018662:c40847-40566 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Nucleotide

• Length: 282 bp

>T70148 NZ_CP018662:c40847-40566 [Salmonella enterica subsp. enterica serovar Enteritidis]
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Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 12380.85 Da
• Isoelectric Point: 5.5500

>AT70148 WP_000121743.1 NZ_CP018662:c41088-40837 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Nucleotide

• Length: 252 bp

>AT70148 NZ_CP018662:c41088-40837 [Salmonella enterica subsp. enterica serovar Enteritidis]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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Structures

Toxin

• AlphaFold DB: G3CAN5

Antitoxin

• AlphaFold DB: A0A3S5I301