Detailed information of TA system TA070145

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 5938..6463
• Replicon: plasmid pSE92-0392
• Accession: NZ_CP018658
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain 92-0392

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: BTN74_RS25595
• Protein ID: WP_001159863.1
• Coordinates: 5938..6243 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: BTN74_RS25600
• Protein ID: WP_000813641.1
• Coordinates: 6245..6463 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTN74_RS25555	1317..1877	-	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-
BTN74_RS26435	2033..2320	+	288	WP_071530243.1	hypothetical protein	-
BTN74_RS25560	2597..3082	-	486	WP_000905606.1	membrane protein	-
BTN74_RS25565	3076..3585	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
BTN74_RS25575	3589..4302	-	714	Protein_7	EAL domain-containing protein	-
BTN74_RS25580	4311..5093	-	783	WP_000082169.1	site-specific integrase	-
BTN74_RS25585	5128..5649	-	522	WP_000198608.1	hypothetical protein	-
BTN74_RS25590	5646..5936	-	291	WP_001266176.1	hypothetical protein	-
BTN74_RS25595	5938..6243	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
BTN74_RS25600	6245..6463	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
BTN74_RS25605	7139..7660	+	522	WP_010999942.1	hypothetical protein	-
BTN74_RS25615	8144..8440	+	297	WP_001687482.1	hypothetical protein	-
BTN74_RS25620	8934..9923	+	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
BTN74_RS25625	10182..10626	-	445	Protein_16	site-specific integrase	-
BTN74_RS25630	10795..11176	-	382	Protein_17	YgiW/YdeI family stress tolerance OB fold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..94039	94039

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T70145 WP_001159863.1 NZ_CP018658:c6243-5938 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T70145 NZ_CP018658:c6243-5938 [Salmonella enterica subsp. enterica serovar Enteritidis]
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Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT70145 WP_000813641.1 NZ_CP018658:c6463-6245 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT70145 NZ_CP018658:c6463-6245 [Salmonella enterica subsp. enterica serovar Enteritidis]
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Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6