Detailed information of TA system TA070142

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 17205..17752
• Replicon: plasmid pSE74-1357
• Accession: NZ_CP018643
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain 74-1357

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: BTN71_RS24095
• Protein ID: WP_000969983.1
• Coordinates: 17205..17486 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5JBQ7
• Locus tag: BTN71_RS24100
• Protein ID: WP_000079943.1
• Coordinates: 17483..17752 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTN71_RS24065	13231..13854	+	624	WP_000904897.1	recombinase family protein	-
BTN71_RS24070	13885..15014	+	1130	WP_085959879.1	IS3-like element IS1133 family transposase	-
BTN71_RS24075	15146..15949	+	804	WP_001082319.1	aminoglycoside O-phosphotransferase APH(3'')-Ib	-
BTN71_RS24080	15949..16785	+	837	WP_000480968.1	aminoglycoside O-phosphotransferase APH(6)-Id	-
BTN71_RS25025	16881..17159	-	279	Protein_17	3'-5' exonuclease	-
BTN71_RS24095	17205..17486	-	282	WP_000969983.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BTN71_RS24100	17483..17752	-	270	WP_000079943.1	hypothetical protein	Antitoxin
BTN71_RS24110	18665..19522	-	858	WP_000130646.1	incFII family plasmid replication initiator RepA	-
BTN71_RS24115	19515..19589	-	75	WP_001365705.1	RepA leader peptide Tap	-
BTN71_RS24125	19827..20081	-	255	WP_000083830.1	replication regulatory protein RepA	-
BTN71_RS24130	20321..20911	-	591	WP_000766807.1	DUF2726 domain-containing protein	-
BTN71_RS24135	20949..21158	-	210	WP_001298565.1	hemolysin expression modulator Hha	-
BTN71_RS24140	21204..21665	-	462	WP_001233838.1	thermonuclease family protein	-
BTN71_RS24145	21910..22122	-	213	WP_001309245.1	ANR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..118824	118824

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 13852.62 Da
• Isoelectric Point: 5.5500

>T70142 WP_000969983.1 NZ_CP018643:c17486-17205 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
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Nucleotide

• Length: 282 bp

>T70142 NZ_CP018643:c17486-17205 [Salmonella enterica subsp. enterica serovar Enteritidis]
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Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 13263.91 Da
• Isoelectric Point: 5.5500

>AT70142 WP_000079943.1 NZ_CP018643:c17752-17483 [Salmonella enterica subsp. enterica serovar Enteritidis]
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FFFFFFFFFF

Nucleotide

• Length: 270 bp

>AT70142 NZ_CP018643:c17752-17483 [Salmonella enterica subsp. enterica serovar Enteritidis]
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Structures

Antitoxin

• AlphaFold DB: A0A622US83