Detailed information of TA system TA070140

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 50150..50675
• Replicon: plasmid pSE69-3861-2
• Accession: NZ_CP018639
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain 69-3861

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: BTN68_RS25015
• Protein ID: WP_001159863.1
• Coordinates: 50150..50455 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: BTN68_RS25020
• Protein ID: WP_000813641.1
• Coordinates: 50457..50675 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTN68_RS24975	45529..46089	-	561	WP_074421875.1	inverse autotransporter beta domain-containing protein	-
BTN68_RS25405	46245..46532	+	288	WP_071530243.1	hypothetical protein	-
BTN68_RS24985	46809..47294	-	486	WP_000905606.1	membrane protein	-
BTN68_RS24990	47288..47797	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
BTN68_RS24995	47801..48514	-	714	WP_000545756.1	EAL domain-containing protein	-
BTN68_RS25000	48523..49305	-	783	WP_000082169.1	site-specific integrase	-
BTN68_RS25005	49340..49861	-	522	WP_000198608.1	hypothetical protein	-
BTN68_RS25010	49858..50148	-	291	WP_001266176.1	hypothetical protein	-
BTN68_RS25015	50150..50455	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
BTN68_RS25020	50457..50675	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
BTN68_RS25025	51351..51872	+	522	WP_077681952.1	hypothetical protein	-
BTN68_RS25410	51916..52344	-	429	Protein_71	hypothetical protein	-
BTN68_RS25035	52356..52651	+	296	Protein_72	cytoplasmic protein	-
BTN68_RS25040	53145..54134	+	990	WP_000461382.1	RepB family plasmid replication initiator protein	-
BTN68_RS25045	54423..54584	-	162	WP_074421876.1	recombinase	-
BTN68_RS25050	54637..55023	-	387	WP_000751876.1	YgiW/YdeI family stress tolerance OB fold protein	-
BTN68_RS25250	55390..55650	-	261	WP_065618785.1	polysaccharide deacetylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..59335	59335

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin YafO (27-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T70140 WP_001159863.1 NZ_CP018639:c50455-50150 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
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Nucleotide

• Length: 306 bp

>T70140 NZ_CP018639:c50455-50150 [Salmonella enterica subsp. enterica serovar Enteritidis]
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Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT70140 WP_000813641.1 NZ_CP018639:c50675-50457 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT70140 NZ_CP018639:c50675-50457 [Salmonella enterica subsp. enterica serovar Enteritidis]
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Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6