Detailed information of TA system TA070139

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 91363..91922
• Replicon: plasmid pSE69-3861-1
• Accession: NZ_CP018638
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain 69-3861

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1PMX5
• Locus tag: BTN68_RS24630
• Protein ID: WP_000421257.1
• Coordinates: 91647..91922 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U9Y625
• Locus tag: BTN68_RS24625
• Protein ID: WP_001178087.1
• Coordinates: 91363..91647 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTN68_RS24580	87008..87541	-	534	WP_001372168.1	transcription termination factor NusG	-
BTN68_RS24590	87983..88270	-	288	WP_000074855.1	conjugal transfer protein TraA	-
BTN68_RS24595	88188..88451	-	264	WP_001387472.1	ash family protein	-
BTN68_RS24610	89424..90455	+	1032	WP_099917992.1	replication initiation protein	-
BTN68_RS24625	91363..91647	+	285	WP_001178087.1	ribbon-helix-helix protein, CopG family	Antitoxin
BTN68_RS24630	91647..91922	+	276	WP_000421257.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BTN68_RS24635	92028..92309	+	282	WP_077124625.1	hypothetical protein	-
BTN68_RS24645	92500..92766	-	267	WP_000627831.1	hypothetical protein	-
BTN68_RS25380	92766..92948	-	183	Protein_110	hypothetical protein	-
BTN68_RS24655	93004..93606	-	603	WP_000517694.1	hypothetical protein	-
BTN68_RS24670	93978..95267	-	1290	WP_000137809.1	ISL3-like element ISPpu12 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..95773	95773

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-261)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-247)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 11810.03 Da
• Isoelectric Point: 12.7590

>T70139 WP_000421257.1 NZ_CP018638:91647-91922 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKK

Nucleotide

• Length: 276 bp

>T70139 NZ_CP018638:91647-91922 [Salmonella enterica subsp. enterica serovar Enteritidis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 12194.55 Da
• Isoelectric Point: 12.7731

>AT70139 WP_001178087.1 NZ_CP018638:91363-91647 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKK

Nucleotide

• Length: 285 bp

>AT70139 NZ_CP018638:91363-91647 [Salmonella enterica subsp. enterica serovar Enteritidis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: S1PMX5

Antitoxin

• AlphaFold DB: U9Y625