Detailed information of TA system TA070137

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 37575..38218
• Replicon: plasmid pSE49-2444
• Accession: NZ_CP018634
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain 49-2444

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: A0A8F2ZUT5
• Locus tag: BTN65_RS24005
• Protein ID: WP_001697179.1
• Coordinates: 37802..38218 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A8F2UWJ1
• Locus tag: BTN65_RS24000
• Protein ID: WP_001261289.1
• Coordinates: 37575..37805 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTN65_RS23955	32963..33448	-	486	WP_000905606.1	membrane protein	-
BTN65_RS23960	33442..33951	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
BTN65_RS23965	33955..34668	-	714	WP_000545756.1	EAL domain-containing protein	-
BTN65_RS23970	34677..35459	-	783	WP_000082169.1	site-specific integrase	-
BTN65_RS23975	35494..36015	-	522	WP_000198608.1	hypothetical protein	-
BTN65_RS23980	36012..36302	-	291	WP_001266176.1	hypothetical protein	-
BTN65_RS23985	36304..36609	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	-
BTN65_RS23990	36611..36829	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	-
BTN65_RS24000	37575..37805	+	231	WP_001261289.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
BTN65_RS24005	37802..38218	+	417	WP_001697179.1	type II toxin-antitoxin system VapC family toxin	Toxin
BTN65_RS24010	38250..38993	+	744	WP_001292424.1	hypothetical protein	-
BTN65_RS24015	39231..40319	+	1089	WP_021003379.1	hypothetical protein	-
BTN65_RS24020	40321..42564	+	2244	WP_001000609.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..92831	92831

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 17834.22 Da
• Isoelectric Point: 12.9398

>T70137 WP_001697179.1 NZ_CP018634:37802-38218 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 417 bp

>T70137 NZ_CP018634:37802-38218 [Salmonella enterica subsp. enterica serovar Enteritidis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 9887.42 Da
• Isoelectric Point: 12.6808

>AT70137 WP_001261289.1 NZ_CP018634:37575-37805 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 231 bp

>AT70137 NZ_CP018634:37575-37805 [Salmonella enterica subsp. enterica serovar Enteritidis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA