Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 5223061..5223708 Replicon chromosome
Accession NZ_CP018632
Organism Granulosicoccus antarcticus IMCC3135

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IMCC3135_RS22680 Protein ID WP_088919665.1
Coordinates 5223061..5223465 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IMCC3135_RS22685 Protein ID WP_088919666.1
Coordinates 5223469..5223708 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMCC3135_RS22660 5219256..5220506 + 1251 WP_205737672.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
IMCC3135_RS22665 5220512..5221174 + 663 WP_088919662.1 riboflavin synthase -
IMCC3135_RS22670 5221167..5222438 + 1272 WP_088919663.1 GTP cyclohydrolase II -
IMCC3135_RS22675 5222506..5222970 + 465 WP_088919664.1 6,7-dimethyl-8-ribityllumazine synthase -
IMCC3135_RS22680 5223061..5223465 - 405 WP_088919665.1 type II toxin-antitoxin system VapC family toxin Toxin
IMCC3135_RS22685 5223469..5223708 - 240 WP_088919666.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
IMCC3135_RS22690 5223801..5223911 + 111 Protein_4477 6,7-dimethyl-8-ribityllumazine synthase -
IMCC3135_RS34285 5224885..5225574 - 690 WP_157736211.1 nucleotidyltransferase domain-containing protein -
IMCC3135_RS22700 5225693..5226604 - 912 WP_088919668.1 homocysteine S-methyltransferase family protein -
IMCC3135_RS22705 5226630..5227970 - 1341 WP_088919669.1 IS4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-124)

Antitoxin

SpoVT-AbrB domain

(10-47)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14458.67 Da        Isoelectric Point: 6.9829

>T70133 WP_088919665.1 NZ_CP018632:c5223465-5223061 [Granulosicoccus antarcticus IMCC3135]
MSFRFMLDTNVISDVIRDPAGKVARQLEFEGESSVCSSIIVASELRYGVAKSGSRELAVRVDAALSAIEILPFDIPADSE
YGKLRALLAAKGTPIGPNDLLIAAHALSLGLTLVTDNVREFKRATGLSVVNWRR

Download         Length: 405 bp

>T70133 NZ_CP018632:c5223465-5223061 [Granulosicoccus antarcticus IMCC3135]
ATGTCTTTCAGATTCATGCTCGACACCAACGTCATTTCTGATGTGATTCGAGATCCGGCAGGTAAGGTGGCCAGACAACT
TGAATTCGAAGGTGAATCAAGTGTATGTAGCAGTATCATTGTTGCGTCAGAACTTAGATATGGTGTTGCAAAAAGCGGCT
CCAGAGAACTGGCCGTGAGAGTGGATGCGGCGTTGTCTGCGATTGAAATACTTCCTTTCGATATCCCCGCAGACAGTGAG
TATGGGAAGCTGCGAGCTCTGCTTGCGGCAAAGGGCACACCAATCGGGCCTAATGATCTGCTAATCGCAGCCCACGCATT
GTCGCTAGGTCTCACATTGGTTACGGATAATGTTCGTGAGTTCAAGCGAGCAACCGGTTTATCGGTAGTCAATTGGCGCA
GATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9066.43 Da        Isoelectric Point: 4.6677

>AT70133 WP_088919666.1 NZ_CP018632:c5223708-5223469 [Granulosicoccus antarcticus IMCC3135]
MTEGRHVKLFRNGRNQAVRIPREFEFEGDEAILRKEGDRLILEPIRTGKLLSVLRALGPMTEPFPDIDDPMPPLDEPDL

Download         Length: 240 bp

>AT70133 NZ_CP018632:c5223708-5223469 [Granulosicoccus antarcticus IMCC3135]
ATGACTGAGGGGCGGCACGTCAAGTTATTTCGCAATGGGCGAAATCAAGCGGTAAGAATTCCCCGAGAGTTCGAGTTTGA
GGGAGATGAGGCAATTCTGCGTAAGGAAGGTGATCGACTGATTCTGGAACCTATCAGGACCGGGAAACTTCTATCTGTTC
TCAGAGCCCTTGGTCCGATGACTGAGCCGTTTCCAGATATCGACGATCCAATGCCGCCATTGGATGAGCCGGATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References