Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 4198874..4200349 Replicon chromosome
Accession NZ_CP018632
Organism Granulosicoccus antarcticus IMCC3135

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag IMCC3135_RS18185 Protein ID WP_088918897.1
Coordinates 4198874..4200130 (-) Length 419 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag IMCC3135_RS18190 Protein ID WP_088918898.1
Coordinates 4200131..4200349 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMCC3135_RS18180 4196399..4198567 - 2169 WP_169727487.1 response regulator -
IMCC3135_RS18185 4198874..4200130 - 1257 WP_088918897.1 type II toxin-antitoxin system HipA family toxin Toxin
IMCC3135_RS18190 4200131..4200349 - 219 WP_088918898.1 helix-turn-helix transcriptional regulator Antitoxin
IMCC3135_RS18195 4200654..4201454 - 801 WP_088918899.1 metallophosphoesterase -
IMCC3135_RS18200 4201532..4201855 - 324 WP_088918900.1 hypothetical protein -
IMCC3135_RS18210 4202677..4203159 + 483 WP_088921923.1 MSMEG_0572 family nitrogen starvation response protein -
IMCC3135_RS18215 4203147..4204190 + 1044 WP_088918902.1 Nit6803 family nitriliase -
IMCC3135_RS18220 4204135..4205253 + 1119 WP_088918903.1 MSMEG_0568 family radical SAM protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-66)


Sequences

Toxin        


Download         Length: 419 a.a.        Molecular weight: 45841.66 Da        Isoelectric Point: 6.1823

>T70132 WP_088918897.1 NZ_CP018632:c4200130-4198874 [Granulosicoccus antarcticus IMCC3135]
VMRKLDVYLRSVNAGLLEQDSTANLTFTYDEDYLASQAARAISVSMPLSRDPYPNAVAKPYFSGLLPDESARTRLAAALG
VSDTNAFGMLEIIGGDCAGALALFPAGAQMPPQNLPDEILDQQQLEELLQELRGNPLLGSRRDVRLSLAGAQDKIAVKVI
GDQIALVKNGEPTTHILKPGIQGLEGTSQNEVFCMTLAARVGLPAPEVAFASTGDTHFILVKRFDRLLRSDQSVQRLHQE
DFCQALSIPPELKYEDEGGPGIDKSLNLLQRVVNQPAADRLAFLRMQIFHYLVGNADAHAKNYALLHTSSADLPELAPLY
DVVCTAVYPQLTQKMAMRIGGRNVPDTIHRNHWLSLVPETRGSQKLLIRELKTLANDIIPAMEKLLADVQELGIGHSILH
DITRVIRTRSQLVLRALP

Download         Length: 1257 bp

>T70132 NZ_CP018632:c4200130-4198874 [Granulosicoccus antarcticus IMCC3135]
GTGATGCGCAAGCTGGATGTCTACCTGCGATCCGTCAATGCGGGTCTGCTTGAGCAGGATAGCACTGCCAATCTGACGTT
TACCTACGACGAGGATTATCTTGCCTCGCAGGCTGCCAGGGCAATTTCTGTCTCCATGCCGTTGAGCCGCGACCCTTACC
CTAATGCTGTCGCCAAACCCTATTTCTCCGGCCTGTTGCCTGATGAATCAGCCCGTACACGACTCGCTGCCGCATTGGGG
GTATCCGACACCAATGCGTTTGGCATGCTGGAAATCATCGGTGGGGACTGTGCGGGCGCCTTGGCACTGTTTCCAGCAGG
CGCACAGATGCCGCCACAGAATTTGCCCGACGAAATTCTTGATCAACAACAACTGGAAGAACTGTTGCAGGAGTTACGCG
GTAACCCGTTGCTGGGTAGTCGTCGAGATGTGCGTCTATCACTGGCGGGTGCACAGGACAAGATTGCCGTCAAAGTGATT
GGGGATCAAATTGCACTGGTCAAGAATGGCGAGCCCACCACGCATATCCTGAAACCTGGCATTCAAGGGCTTGAAGGAAC
CTCACAGAATGAAGTGTTTTGTATGACACTGGCAGCACGGGTTGGTCTGCCAGCACCAGAGGTTGCGTTTGCCAGTACAG
GCGACACTCATTTCATTCTGGTAAAACGCTTTGATCGATTATTGCGAAGCGACCAGTCAGTGCAACGCTTGCATCAGGAA
GATTTCTGCCAGGCCTTGAGCATTCCACCAGAGCTTAAATACGAAGATGAAGGTGGGCCTGGCATCGACAAATCGTTGAA
TCTGTTGCAGCGAGTTGTCAATCAGCCTGCTGCTGACAGGCTGGCCTTTCTGCGAATGCAAATCTTCCACTATCTGGTTG
GTAACGCTGATGCTCATGCGAAGAATTACGCACTGCTACACACATCCAGCGCTGATTTACCTGAGCTGGCACCGCTTTAC
GATGTCGTCTGCACGGCCGTCTATCCACAATTGACTCAAAAAATGGCCATGCGTATTGGCGGTAGAAATGTTCCTGACAC
TATCCATCGCAATCACTGGTTATCGCTGGTACCCGAGACCAGAGGCTCACAAAAATTGCTCATCAGAGAGCTGAAAACAC
TTGCCAATGATATTATCCCTGCAATGGAAAAACTGCTGGCAGATGTACAGGAACTTGGAATAGGACATTCGATATTGCAT
GACATTACCAGGGTGATCAGGACACGCTCGCAGTTGGTATTGCGCGCATTACCTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8023.24 Da        Isoelectric Point: 9.4082

>AT70132 WP_088918898.1 NZ_CP018632:c4200349-4200131 [Granulosicoccus antarcticus IMCC3135]
MTTILNAEMLGEVIRRERKRQKVTQSDLAALAGVGVRFLRELEHGKSSCQLGRTLEVLQTLGISVDANTREQ

Download         Length: 219 bp

>AT70132 NZ_CP018632:c4200349-4200131 [Granulosicoccus antarcticus IMCC3135]
ATGACAACAATACTCAATGCTGAAATGCTCGGCGAAGTCATTCGCAGGGAGCGTAAGCGACAGAAGGTGACGCAGTCAGA
CCTGGCCGCACTGGCAGGGGTCGGTGTGCGTTTTTTGCGCGAACTGGAGCACGGTAAAAGCAGTTGTCAGCTTGGCCGGA
CGCTGGAGGTGCTGCAGACACTCGGCATTTCTGTTGACGCCAACACGCGGGAACAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References