Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 2234814..2235439 Replicon chromosome
Accession NZ_CP018629
Organism Staphylococcus aureus strain MRSA107

Toxin (Protein)


Gene name doc Uniprot ID A0A380FZ43
Locus tag BTN44_RS12050 Protein ID WP_001179607.1
Coordinates 2234814..2235209 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A380FXS4
Locus tag BTN44_RS12055 Protein ID WP_000258939.1
Coordinates 2235209..2235439 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTN44_RS12010 2230369..2230809 - 441 Protein_2232 GNAT family N-acetyltransferase -
BTN44_RS12015 2230784..2231035 - 252 WP_002505594.1 hypothetical protein -
BTN44_RS12020 2231032..2231667 - 636 Protein_2234 aminoglycoside 6-adenylyltransferase -
BTN44_RS12025 2231882..2232604 - 723 WP_001043218.1 hypothetical protein -
BTN44_RS12030 2232713..2233513 - 801 WP_000686449.1 metallophosphoesterase -
BTN44_RS12035 2233517..2234011 - 495 WP_000280790.1 hypothetical protein -
BTN44_RS12040 2234068..2234337 - 270 WP_000755772.1 hypothetical protein -
BTN44_RS12045 2234321..2234512 - 192 WP_032605691.1 hypothetical protein -
BTN44_RS12050 2234814..2235209 - 396 WP_001179607.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
BTN44_RS12055 2235209..2235439 - 231 WP_000258939.1 addiction module antitoxin Antitoxin
BTN44_RS12060 2235615..2236136 - 522 WP_000639078.1 metallophosphoesterase -
BTN44_RS12065 2236136..2236786 - 651 WP_000411528.1 hypothetical protein -
BTN44_RS12070 2236786..2237103 - 318 WP_001807410.1 hypothetical protein -
BTN44_RS12075 2237096..2237821 - 726 WP_000197304.1 metallophosphoesterase -
BTN44_RS12080 2237821..2238042 - 222 WP_000829423.1 hypothetical protein -
BTN44_RS16620 2238062..2238238 - 177 WP_000063384.1 hypothetical protein -
BTN44_RS12085 2238231..2238773 - 543 WP_000858632.1 hypothetical protein -
BTN44_RS12090 2238788..2239060 - 273 WP_000691100.1 hypothetical protein -
BTN44_RS12095 2239086..2239241 - 156 WP_000792995.1 transcriptional regulator -
BTN44_RS16625 2239355..2239522 - 168 WP_000312832.1 hypothetical protein -
BTN44_RS12100 2239538..2239723 - 186 WP_001187008.1 hypothetical protein -
BTN44_RS12105 2239708..2239887 - 180 WP_000401832.1 hypothetical protein -
BTN44_RS12110 2239901..2240383 - 483 WP_000833764.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage aac(6')-aph(2'') / aph(3')-III - 2195885..2324452 128567


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 15035.51 Da        Isoelectric Point: 9.4574

>T70121 WP_001179607.1 NZ_CP018629:c2235209-2234814 [Staphylococcus aureus]
MQNIKYLTEKQVIAINVKAIQELSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFFNANKR
TAFTSMVIFLKLNKINFNCTQDEAVQFTLKVVEDKTLTLEDIADWIKRHCK

Download         Length: 396 bp

>T70121 NZ_CP018629:c2235209-2234814 [Staphylococcus aureus]
ATGCAAAACATTAAATATTTAACTGAAAAACAAGTAATTGCCATTAATGTAAAAGCAATTCAAGAACTCTCACCTAAAGA
ACAAGTTGGTGTTAAAGTTCCAGAGGTTCTTAATGCTACTATTGAAGGAGTTAAACAATCATTTGGTGGAGTTGAACTAT
ATGAAACAATCGAGAGAAAAGCGGCTTTTATATACAGAAATATAGCTCAAAAACATGCATTCTTTAATGCGAATAAGAGA
ACAGCTTTTACATCTATGGTTATTTTCTTGAAGTTAAATAAGATTAATTTTAATTGTACTCAAGACGAAGCGGTACAATT
TACTTTAAAAGTGGTAGAGGATAAAACTCTTACACTTGAAGATATTGCAGATTGGATCAAAAGGCATTGTAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8617.73 Da        Isoelectric Point: 4.4501

>AT70121 WP_000258939.1 NZ_CP018629:c2235439-2235209 [Staphylococcus aureus]
MVTTRKLRRAGNSSVVSVPTEVIAALGVTNGDNLKFNIEDNKVTIEKEVNEDEEFFKLLDETFTEYNQALRKLVDI

Download         Length: 231 bp

>AT70121 NZ_CP018629:c2235439-2235209 [Staphylococcus aureus]
ATGGTTACTACAAGAAAACTAAGAAGAGCTGGCAATAGTTCAGTTGTTTCTGTACCAACAGAAGTGATCGCAGCACTCGG
AGTTACAAATGGTGACAATCTTAAATTTAATATTGAAGATAATAAAGTAACCATTGAAAAGGAGGTAAACGAAGACGAAG
AGTTTTTCAAATTGTTGGATGAAACATTCACTGAGTATAACCAAGCTCTGAGAAAGTTGGTTGACATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380FZ43

Antitoxin

Source ID Structure
AlphaFold DB A0A380FXS4

References