Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1602495..1602972 Replicon chromosome
Accession NZ_CP018629
Organism Staphylococcus aureus strain MRSA107

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag BTN44_RS08525 Protein ID WP_000052078.1
Coordinates 1602784..1602972 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag BTN44_RS08520 Protein ID WP_001059690.1
Coordinates 1602495..1602755 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTN44_RS08485 1597888..1598604 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
BTN44_RS08490 1598752..1599174 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
BTN44_RS08495 1599573..1600067 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
BTN44_RS08500 1600222..1600839 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
BTN44_RS08505 1600912..1601493 - 582 WP_001140686.1 phosphoglycerate mutase family protein -
BTN44_RS08510 1601718..1601954 + 237 WP_000368687.1 hypothetical protein -
BTN44_RS08515 1601951..1602154 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
BTN44_RS08520 1602495..1602755 + 261 WP_001059690.1 hypothetical protein Antitoxin
BTN44_RS08525 1602784..1602972 + 189 WP_000052078.1 hypothetical protein Toxin
BTN44_RS08530 1603160..1603729 + 570 WP_001106654.1 hypothetical protein -
BTN44_RS08535 1603817..1604101 + 285 WP_001004395.1 hypothetical protein -
BTN44_RS08540 1604163..1604381 + 219 WP_000005886.1 hypothetical protein -
BTN44_RS08545 1604878..1605078 - 201 WP_001059082.1 cold-shock protein -
BTN44_RS08550 1605435..1606121 - 687 WP_001548082.1 thermonuclease family protein -
BTN44_RS08555 1606462..1606932 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selq / selk / vWbp 1578228..1620789 42561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T70117 WP_000052078.1 NZ_CP018629:1602784-1602972 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T70117 NZ_CP018629:1602784-1602972 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT70117 WP_001059690.1 NZ_CP018629:1602495-1602755 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT70117 NZ_CP018629:1602495-1602755 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References