Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 1585351..1585856 Replicon chromosome
Accession NZ_CP018629
Organism Staphylococcus aureus strain MRSA107

Toxin (Protein)


Gene name TscT Uniprot ID A0A0C6E6D5
Locus tag BTN44_RS08380 Protein ID WP_001103946.1
Coordinates 1585351..1585644 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID X5IA75
Locus tag BTN44_RS08385 Protein ID WP_001058492.1
Coordinates 1585647..1585856 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTN44_RS08350 1580542..1580883 - 342 WP_001190616.1 hypothetical protein -
BTN44_RS08355 1581332..1581973 - 642 WP_001019783.1 hypothetical protein -
BTN44_RS08360 1581970..1582254 - 285 WP_000998180.1 hypothetical protein -
BTN44_RS08365 1582256..1582618 - 363 WP_001039172.1 hypothetical protein -
BTN44_RS08370 1582920..1584377 - 1458 WP_000432707.1 virulence-associated E family protein -
BTN44_RS08375 1584394..1585263 - 870 WP_001002691.1 primase alpha helix C-terminal domain-containing protein -
BTN44_RS08380 1585351..1585644 - 294 WP_001103946.1 DUF1474 family protein Toxin
BTN44_RS08385 1585647..1585856 - 210 WP_001058492.1 hypothetical protein Antitoxin
BTN44_RS08390 1585849..1585995 - 147 WP_000784885.1 hypothetical protein -
BTN44_RS08395 1586007..1586279 - 273 WP_001138298.1 helix-turn-helix domain-containing protein -
BTN44_RS08400 1586280..1586492 - 213 WP_001063624.1 helix-turn-helix transcriptional regulator -
BTN44_RS08405 1586642..1587376 + 735 WP_000142630.1 helix-turn-helix domain-containing protein -
BTN44_RS08410 1587551..1588279 + 729 WP_001033317.1 staphylococcal enterotoxin type Q -
BTN44_RS08415 1588303..1589031 + 729 WP_000733773.1 staphylococcal enterotoxin type K -
BTN44_RS08420 1589119..1590339 + 1221 WP_000264182.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selq / selk / vWbp 1578228..1620789 42561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-97)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11590.08 Da        Isoelectric Point: 4.9594

>T70116 WP_001103946.1 NZ_CP018629:c1585644-1585351 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASLQADQSESNA

Download         Length: 294 bp

>T70116 NZ_CP018629:c1585644-1585351 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAAGTGTACTTAAAAGAGTTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCGTCACTTCAAGCCGATCAAAGCGAAAGTAACGCATAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8238.28 Da        Isoelectric Point: 4.3718

>AT70116 WP_001058492.1 NZ_CP018629:c1585856-1585647 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT70116 NZ_CP018629:c1585856-1585647 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C6E6D5

Antitoxin

Source ID Structure
AlphaFold DB X5IA75

References