Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 877690..878487 Replicon chromosome
Accession NZ_CP018629
Organism Staphylococcus aureus strain MRSA107

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag BTN44_RS04785 Protein ID WP_000525004.1
Coordinates 877690..878151 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0C2LD36
Locus tag BTN44_RS04790 Protein ID WP_001260487.1
Coordinates 878164..878487 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTN44_RS04760 874635..875840 - 1206 WP_000264747.1 site-specific integrase -
BTN44_RS04765 875966..876580 + 615 WP_000191466.1 hypothetical protein -
BTN44_RS04770 876577..876723 - 147 WP_001013104.1 hypothetical protein -
BTN44_RS04775 876814..877209 - 396 WP_000449655.1 hypothetical protein -
BTN44_RS04780 877238..877672 - 435 WP_103067868.1 hypothetical protein -
BTN44_RS04785 877690..878151 - 462 WP_000525004.1 hypothetical protein Toxin
BTN44_RS04790 878164..878487 - 324 WP_001260487.1 helix-turn-helix domain-containing protein Antitoxin
BTN44_RS04795 878651..878898 + 248 Protein_876 helix-turn-helix transcriptional regulator -
BTN44_RS04800 878911..879354 + 444 WP_000435355.1 hypothetical protein -
BTN44_RS04805 879369..879548 + 180 WP_000393082.1 hypothetical protein -
BTN44_RS04810 879538..879777 - 240 WP_000438628.1 hypothetical protein -
BTN44_RS04815 879834..880586 + 753 WP_031867169.1 phage antirepressor KilAC domain-containing protein -
BTN44_RS04820 880602..880745 + 144 WP_000939502.1 hypothetical protein -
BTN44_RS04825 880735..880944 - 210 WP_103067869.1 hypothetical protein -
BTN44_RS04830 881015..881236 + 222 WP_000594789.1 hypothetical protein -
BTN44_RS04835 881229..881390 + 162 WP_103067870.1 DUF1270 family protein -
BTN44_RS04840 881460..881789 + 330 WP_103067871.1 hypothetical protein -
BTN44_RS04845 881770..882030 + 261 WP_142758934.1 DUF1108 family protein -
BTN44_RS04850 882044..882406 + 363 WP_000985979.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T70115 WP_000525004.1 NZ_CP018629:c878151-877690 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T70115 NZ_CP018629:c878151-877690 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTGATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGGATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCTGTTCCATTACGCGAAATTGTAGAAGCTTATAATTATGGCGTACGTAACTTGTATGAATT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCGATCACATTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12431.09 Da        Isoelectric Point: 9.3811

>AT70115 WP_001260487.1 NZ_CP018629:c878487-878164 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT70115 NZ_CP018629:c878487-878164 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAGA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGTGCA
GCTCATTTAGAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LD36

References