Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 2192390..2193038 Replicon chromosome
Accession NZ_CP018622
Organism Virgibacillus dokdonensis strain 21D

Toxin (Protein)


Gene name pemK Uniprot ID A0A3E0WNY0
Locus tag A21D_RS10025 Protein ID WP_073013075.1
Coordinates 2192679..2193038 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag A21D_RS10020 Protein ID WP_077706817.1
Coordinates 2192390..2192674 (+) Length 95 a.a.

Genomic Context

A21D_RS10005A21D_RS10010A21D_RS10015A21D_RS10020A21D_RS10025A21D_RS10030A21D_RS10035A21D_RS10040A21D_RS10045A21D_RS10050A21D_RS10055
Location: 2187698..2189219 (1522 bp)
Type: Others
Protein ID: Protein_1973
Location: 2189391..2190401 (1011 bp)
Type: Others
Protein ID: WP_101933372.1
Location: 2190825..2191946 (1122 bp)
Type: Others
Protein ID: WP_101933373.1
Location: 2192390..2192674 (285 bp)
Type: Antitoxin
Protein ID: WP_077706817.1
Location: 2192679..2193038 (360 bp)
Type: Toxin
Protein ID: WP_073013075.1
Location: 2193372..2194241 (870 bp)
Type: Others
Protein ID: WP_077702490.1
Location: 2194238..2194603 (366 bp)
Type: Others
Protein ID: WP_170861785.1
Location: 2194607..2195008 (402 bp)
Type: Others
Protein ID: WP_073013081.1
Location: 2195219..2196232 (1014 bp)
Type: Others
Protein ID: WP_077702491.1
Location: 2196501..2196836 (336 bp)
Type: Others
Protein ID: WP_101933374.1
Location: 2196833..2197318 (486 bp)
Type: Others
Protein ID: WP_176087389.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A21D_RS100052187698..2189219+1522Protein_1973NAD(P)H-hydrate dehydratase-
A21D_RS100102189391..2190401+1011WP_101933372.1outer membrane lipoprotein carrier protein LolA-
A21D_RS100152190825..2191946+1122WP_101933373.1alanine racemase-
A21D_RS100202192390..2192674+285WP_077706817.1antitoxinAntitoxin
A21D_RS100252192679..2193038+360WP_073013075.1type II toxin-antitoxin system PemK/MazF family toxinToxin
A21D_RS100302193372..2194241+870WP_077702490.1RsbT co-antagonist protein RsbRA-
A21D_RS100352194238..2194603+366WP_170861785.1STAS domain-containing protein-
A21D_RS100402194607..2195008+402WP_073013081.1anti-sigma regulatory factor-
A21D_RS100452195219..2196232+1014WP_077702491.1PP2C family protein-serine/threonine phosphatase-
A21D_RS100502196501..2196836+336WP_101933374.1STAS domain-containing protein-
A21D_RS100552196833..2197318+486WP_176087389.1anti-sigma B factor RsbW-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13413.60 Da        Isoelectric Point: 7.0134

>T70101 WP_073013075.1 NZ_CP018622:2192679-2193038 [Virgibacillus dokdonensis]
MIVQRGEVYFADLSPVVGSEQGGVRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKQYGFDRDSVILLEQI
RTLDKQRLTDKITKLDKEKMKMINQALEISLGLKDMYDQ

Download         Length: 360 bp

>T70101 NZ_CP018622:2192679-2193038 [Virgibacillus dokdonensis]
TTGATCGTACAAAGAGGCGAAGTGTATTTCGCTGACCTTTCCCCTGTTGTTGGATCAGAGCAGGGAGGCGTCCGCCCGGT
ATTGATCCTGCAAAATGATATCGGGAATCGTTTCAGTCCTACCGTTATTGTGGCTGCAATTACAGCACAAATTCAAAAAG
CTAAACTCCCTACACATGTGGAGATTGATGCAAAACAATATGGGTTTGACCGTGATTCCGTTATTTTGCTAGAGCAGATA
CGAACACTTGATAAACAAAGGCTAACAGATAAAATTACAAAGTTAGATAAAGAAAAGATGAAAATGATTAACCAAGCATT
AGAAATCAGTTTAGGGCTGAAGGATATGTATGATCAATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10898.32 Da        Isoelectric Point: 4.5792

>AT70101 WP_077706817.1 NZ_CP018622:2192390-2192674 [Virgibacillus dokdonensis]
MSESLQEVLVKIPKNLLNEVDGLMKYENSDLSDFICQATRNYLQHKRDEHFQQFRETMEKGYAEMGRINLTIASEAFQAE
EEAKITLERSVIGV

Download         Length: 285 bp

>AT70101 NZ_CP018622:2192390-2192674 [Virgibacillus dokdonensis]
TTGTCAGAAAGCTTGCAAGAAGTATTAGTGAAAATACCAAAAAACCTGTTAAATGAGGTGGATGGTCTGATGAAATATGA
GAATAGTGATTTAAGTGATTTCATATGTCAGGCAACTAGAAACTATCTTCAGCATAAAAGAGATGAGCATTTTCAACAAT
TTCGCGAAACCATGGAAAAGGGCTATGCAGAAATGGGTCGCATTAATTTGACAATTGCTTCTGAAGCTTTTCAAGCGGAA
GAAGAAGCAAAAATCACCTTGGAACGCTCTGTGATCGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A3E0WNY0

Antitoxin

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Source
ID
Structure
No matching records found

References