Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | BrnTA/BrnT-BrnA |
Location | 961880..962439 | Replicon | chromosome |
Accession | NZ_CP018526 | ||
Organism | Brucella melitensis strain BwIM_SYR_26 |
Toxin (Protein)
Gene name | brnT | Uniprot ID | A0A7U8PD14 |
Locus tag | BK185_RS05030 | Protein ID | WP_002966807.1 |
Coordinates | 962194..962439 (-) | Length | 82 a.a. |
Antitoxin (Protein)
Gene name | brnA | Uniprot ID | C0RIV1 |
Locus tag | BK185_RS05025 | Protein ID | WP_004683740.1 |
Coordinates | 961880..962194 (-) | Length | 105 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BK185_RS04975 | 957585..957788 | - | 204 | WP_004683737.1 | hypothetical protein | - |
BK185_RS04980 | 957791..958006 | - | 216 | WP_005968947.1 | hypothetical protein | - |
BK185_RS04985 | 958003..958206 | - | 204 | WP_002964088.1 | hypothetical protein | - |
BK185_RS04990 | 958256..958960 | + | 705 | WP_005968944.1 | hypothetical protein | - |
BK185_RS04995 | 958957..959187 | + | 231 | WP_002964091.1 | hypothetical protein | - |
BK185_RS05000 | 959184..959459 | + | 276 | WP_002964092.1 | hypothetical protein | - |
BK185_RS05005 | 959482..959958 | + | 477 | WP_002966806.1 | hypothetical protein | - |
BK185_RS05010 | 960304..961014 | + | 711 | WP_004683739.1 | porin family protein | - |
BK185_RS05015 | 961362..961532 | - | 171 | WP_002964095.1 | DUF1508 domain-containing protein | - |
BK185_RS05025 | 961880..962194 | - | 315 | WP_004683740.1 | BrnA antitoxin family protein | Antitoxin |
BK185_RS05030 | 962194..962439 | - | 246 | WP_002966807.1 | BrnT family toxin | Toxin |
BK185_RS05035 | 962572..963210 | + | 639 | Protein_923 | tRNA-guanine transglycosylase | - |
BK185_RS05040 | 963280..964038 | + | 759 | Protein_924 | IS5 family transposase | - |
BK185_RS05045 | 964039..964731 | + | 693 | WP_006135935.1 | hypothetical protein | - |
BK185_RS05050 | 965143..966594 | + | 1452 | WP_006135932.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | wboA / wbdA | 955813..969910 | 14097 | |
- | flank | IS/Tn | - | - | 963280..963648 | 368 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 82 a.a. Molecular weight: 9162.82 Da Isoelectric Point: 10.3158
>T70091 WP_002966807.1 NZ_CP018526:c962439-962194 [Brucella melitensis]
MKIIWDEPKRQTNIAKHGLDFADLHFEFFLSAKVFPTKADRLMAIGEFNGLIIIAVIFKPVGSEALSVISMRSASQKERK
L
MKIIWDEPKRQTNIAKHGLDFADLHFEFFLSAKVFPTKADRLMAIGEFNGLIIIAVIFKPVGSEALSVISMRSASQKERK
L
Download Length: 246 bp
>T70091 NZ_CP018526:c962439-962194 [Brucella melitensis]
ATGAAGATCATCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCCTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCATTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTTCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA
ATGAAGATCATCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCCTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCATTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTTCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11653.48 Da Isoelectric Point: 10.5824
>AT70091 WP_004683740.1 NZ_CP018526:c962194-961880 [Brucella melitensis]
MGIKFSSKRPLTQEEEAEIQKMIASDPDAPEATDKQLAKAKPFKESFPDMAAKMEKAIRGRPRIDNPKTPVTIRLDQDVV
QRFKATGKGWQGRMNDALRKAVGL
MGIKFSSKRPLTQEEEAEIQKMIASDPDAPEATDKQLAKAKPFKESFPDMAAKMEKAIRGRPRIDNPKTPVTIRLDQDVV
QRFKATGKGWQGRMNDALRKAVGL
Download Length: 315 bp
>AT70091 NZ_CP018526:c962194-961880 [Brucella melitensis]
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAGGAAGAGGCAGAAATTCAGAAGATGATCGCAAGCGATCC
CGATGCACCGGAAGCCACCGATAAACAGCTTGCCAAGGCCAAGCCTTTCAAGGAATCCTTTCCAGATATGGCCGCCAAGA
TGGAGAAGGCCATTCGAGGCCGGCCGCGCATCGACAATCCCAAGACGCCGGTTACTATCCGGCTCGATCAGGATGTAGTT
CAACGCTTCAAGGCCACCGGCAAAGGCTGGCAGGGCCGTATGAACGATGCCCTGCGCAAAGCTGTCGGGCTTTGA
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAGGAAGAGGCAGAAATTCAGAAGATGATCGCAAGCGATCC
CGATGCACCGGAAGCCACCGATAAACAGCTTGCCAAGGCCAAGCCTTTCAAGGAATCCTTTCCAGATATGGCCGCCAAGA
TGGAGAAGGCCATTCGAGGCCGGCCGCGCATCGACAATCCCAAGACGCCGGTTACTATCCGGCTCGATCAGGATGTAGTT
CAACGCTTCAAGGCCACCGGCAAAGGCTGGCAGGGCCGTATGAACGATGCCCTGCGCAAAGCTGTCGGGCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U8PD14 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | C0RIV1 |