Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4186346..4186965 Replicon chromosome
Accession NZ_CP018447
Organism Klebsiella pneumoniae strain Kp_Goe_33208

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag BB747_RS21775 Protein ID WP_002892050.1
Coordinates 4186747..4186965 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag BB747_RS21770 Protein ID WP_002892066.1
Coordinates 4186346..4186720 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB747_RS21760 4181498..4182691 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
BB747_RS21765 4182714..4185860 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
BB747_RS21770 4186346..4186720 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
BB747_RS21775 4186747..4186965 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
BB747_RS21780 4187124..4187690 + 567 WP_002892030.1 maltose O-acetyltransferase -
BB747_RS31265 4187662..4187802 - 141 WP_004147370.1 hypothetical protein -
BB747_RS21790 4187823..4188293 + 471 WP_002892026.1 YlaC family protein -
BB747_RS21795 4188268..4189719 - 1452 WP_032419337.1 PLP-dependent aminotransferase family protein -
BB747_RS21800 4189820..4190518 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
BB747_RS21805 4190515..4190655 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
BB747_RS21810 4190655..4190918 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T70023 WP_002892050.1 NZ_CP018447:4186747-4186965 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T70023 NZ_CP018447:4186747-4186965 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT70023 WP_002892066.1 NZ_CP018447:4186346-4186720 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT70023 NZ_CP018447:4186346-4186720 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References