Detailed information of TA system TA069934

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2357974..2358653
• Replicon: chromosome
• Accession: NZ_CP018421
• Organism: Acinetobacter baumannii strain XDR-BJ83 isolate male patient

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: BS615_RS11125
• Protein ID: WP_000838146.1
• Coordinates: 2358471..2358653 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: BS615_RS11120
• Protein ID: WP_000966688.1
• Coordinates: 2357974..2358378 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BS615_RS11090	2354986..2355978	-	993	WP_000835645.1	KilA-N domain-containing protein	-
BS615_RS11095	2355975..2356130	-	156	WP_001103649.1	Arc family DNA-binding protein	-
BS615_RS11100	2356253..2356492	+	240	WP_000763623.1	Arc family DNA-binding protein	-
BS615_RS11105	2356541..2357335	-	795	WP_000720608.1	hypothetical protein	-
BS615_RS11110	2357367..2357690	-	324	WP_000523922.1	DUF4236 domain-containing protein	-
BS615_RS11115	2357699..2357875	-	177	WP_014466185.1	hypothetical protein	-
BS615_RS11120	2357974..2358378	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BS615_RS11125	2358471..2358653	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
BS615_RS11135	2358979..2359488	-	510	WP_038338755.1	hypothetical protein	-
BS615_RS11140	2359559..2360476	-	918	WP_020752401.1	hypothetical protein	-
BS615_RS11145	2360571..2361554	-	984	WP_020752400.1	hypothetical protein	-
BS615_RS11150	2361554..2361904	-	351	WP_020752399.1	hypothetical protein	-
BS615_RS11155	2362000..2362218	-	219	WP_020752398.1	hypothetical protein	-
BS615_RS11160	2362220..2362663	-	444	WP_073545229.1	hypothetical protein	-
BS615_RS11165	2362620..2362988	-	369	WP_020752396.1	hypothetical protein	-
BS615_RS11170	2362960..2363364	-	405	WP_020752395.1	hypothetical protein	-
BS615_RS20410	2363376..2363546	-	171	WP_005119785.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2337722..2406092	68370

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T69934 WP_000838146.1 NZ_CP018421:c2358653-2358471 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T69934 NZ_CP018421:c2358653-2358471 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT69934 WP_000966688.1 NZ_CP018421:c2358378-2357974 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT69934 NZ_CP018421:c2358378-2357974 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6