Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 2892461..2893074 Replicon chromosome
Accession NZ_CP018420
Organism Pseudomonas veronii strain R02

Toxin (Protein)


Gene name hicA Uniprot ID A0A1X7GMT0
Locus tag PverR02_RS13495 Protein ID WP_027607491.1
Coordinates 2892823..2893074 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2N7YF18
Locus tag PverR02_RS13490 Protein ID WP_046488352.1
Coordinates 2892461..2892826 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PverR02_RS13465 2887791..2888138 + 348 WP_046383751.1 zinc ribbon domain-containing protein -
PverR02_RS13470 2888154..2889197 + 1044 WP_079443618.1 aliphatic amidase -
PverR02_RS13475 2889294..2889866 + 573 WP_057004783.1 DUF2239 family protein -
PverR02_RS13480 2889892..2891247 + 1356 WP_046488356.1 MATE family efflux transporter -
PverR02_RS13485 2891288..2892460 + 1173 WP_046383747.1 MFS transporter -
PverR02_RS13490 2892461..2892826 - 366 WP_046488352.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PverR02_RS13495 2892823..2893074 - 252 WP_027607491.1 type II toxin-antitoxin system HicA family toxin Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9509.10 Da        Isoelectric Point: 10.0458

>T69932 WP_027607491.1 NZ_CP018420:c2893074-2892823 [Pseudomonas veronii]
VSKNEKLLAKLLNEQMAFTWPELVTLLRRLGYTQIEGAGSRVKFDIGDPSAMITLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Download         Length: 252 bp

>T69932 NZ_CP018420:c2893074-2892823 [Pseudomonas veronii]
GTGTCCAAAAATGAAAAGCTGCTCGCCAAACTGCTCAACGAGCAAATGGCATTTACCTGGCCCGAGCTCGTCACGCTGCT
GCGTCGTCTTGGCTACACACAGATTGAAGGGGCGGGAAGCCGCGTCAAGTTCGACATCGGCGACCCCAGTGCAATGATCA
CCTTGCACAAGCCTCACCCCGGCAATGAACTGAAACACTACATTCGGCGCCAGATCATCGAACAATTGAAATCAGGAGAA
CTGATTCAGTGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13164.13 Da        Isoelectric Point: 6.9478

>AT69932 WP_046488352.1 NZ_CP018420:c2892826-2892461 [Pseudomonas veronii]
VNNQLKHQGYIGSIEASLEDNCLFGKILFIKALVSYEGKTVAELDAAFREAVDDYLATCLALGQTPEKPCKGSFNVRVGH
DLHLAAALEATRKKVTLNDLTRQALSEFLLHHCAKPTPAIG

Download         Length: 366 bp

>AT69932 NZ_CP018420:c2892826-2892461 [Pseudomonas veronii]
GTGAACAACCAATTGAAACACCAAGGCTACATCGGCTCCATCGAAGCCAGCCTCGAAGACAACTGCCTGTTCGGCAAGAT
CCTGTTTATCAAGGCGCTGGTGAGCTACGAAGGGAAAACCGTCGCCGAACTGGATGCGGCATTTCGTGAGGCGGTGGACG
ACTATCTCGCCACCTGCCTGGCCCTTGGGCAAACACCGGAAAAACCATGCAAGGGTTCATTCAACGTGCGGGTCGGGCAT
GACCTTCATCTGGCCGCAGCCCTGGAAGCTACACGCAAGAAGGTGACCCTGAACGACCTGACACGCCAAGCGCTGAGTGA
GTTCCTGCTACATCACTGCGCCAAACCCACCCCCGCGATCGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X7GMT0

Antitoxin

Source ID Structure
AlphaFold DB A0A2N7YF18

References