Detailed information of TA system TA069931

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1612043..1612658
• Replicon: chromosome
• Accession: NZ_CP018420
• Organism: Pseudomonas veronii strain R02

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0R3AY05
• Locus tag: PverR02_RS07345
• Protein ID: WP_057004762.1
• Coordinates: 1612476..1612658 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: PverR02_RS07340
• Protein ID: WP_079443027.1
• Coordinates: 1612043..1612453 (-)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PverR02_RS07305	1607396..1608073	+	678	WP_079443024.1	NAD(P)H-binding protein	-
PverR02_RS07310	1608074..1608562	-	489	WP_079443025.1	DMT family transporter	-
PverR02_RS07315	1608631..1609557	+	927	WP_046384398.1	LysR family transcriptional regulator	-
PverR02_RS07320	1609571..1609981	+	411	WP_046384397.1	fosfomycin resistance glutathione transferase	-
PverR02_RS07325	1610036..1610677	+	642	WP_046384396.1	LysE family translocator	-
PverR02_RS07330	1610794..1611321	+	528	WP_079443026.1	DUF4142 domain-containing protein	-
PverR02_RS07335	1611414..1611914	-	501	WP_046490294.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
PverR02_RS07340	1612043..1612453	-	411	WP_079443027.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
PverR02_RS07345	1612476..1612658	-	183	WP_057004762.1	type II toxin-antitoxin system HicA family toxin	Toxin
PverR02_RS07350	1612807..1613709	-	903	WP_079443028.1	LysR family transcriptional regulator	-
PverR02_RS07355	1613805..1614968	+	1164	WP_057004763.1	MFS transporter	-
PverR02_RS07360	1614965..1616158	+	1194	WP_079443029.1	MFS transporter	-
PverR02_RS07365	1616240..1616608	-	369	WP_079443030.1	BrnA antitoxin family protein	-
PverR02_RS07370	1616577..1616894	-	318	WP_079443031.1	BrnT family toxin	-
PverR02_RS07375	1617117..1617422	-	306	WP_017844869.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6767.99 Da
• Isoelectric Point: 10.7532

>T69931 WP_057004762.1 NZ_CP018420:c1612658-1612476 [Pseudomonas veronii]
VDSRYLIGHIVADGWYLVRVRGSHHPFKHPTKPGLVTIPHPKKDLLDKTAKSMLKQALLS

Nucleotide

• Length: 183 bp

>T69931 NZ_CP018420:c1612658-1612476 [Pseudomonas veronii]
GTGGATAGCCGATATTTAATAGGCCATATCGTCGCCGACGGCTGGTATCTGGTGCGCGTCAGAGGTAGCCATCACCCCTT
CAAGCACCCGACGAAACCGGGGCTGGTGACAATTCCTCATCCGAAGAAGGACTTGTTGGACAAGACCGCCAAAAGCATGT
TGAAACAGGCACTGCTGAGTTAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14804.78 Da
• Isoelectric Point: 4.5036

>AT69931 WP_079443027.1 NZ_CP018420:c1612453-1612043 [Pseudomonas veronii]
VLYPIAISTGDEDHAWGVEVPDIPGCYSAGDDLDDAMAMAREAIEGHFEILAEDGAPIPSAQKVTLHAANPKYAGCMWAV
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQDR

Nucleotide

• Length: 411 bp

>AT69931 NZ_CP018420:c1612453-1612043 [Pseudomonas veronii]
GTGCTGTACCCCATCGCAATTTCTACTGGTGACGAAGACCATGCCTGGGGCGTGGAAGTCCCGGACATTCCTGGTTGCTA
CTCCGCCGGTGACGACTTGGACGACGCCATGGCCATGGCCCGTGAAGCGATTGAAGGCCACTTCGAAATTCTCGCCGAAG
ACGGTGCGCCGATTCCCAGCGCGCAGAAAGTCACCCTGCATGCAGCCAACCCCAAGTACGCCGGTTGCATGTGGGCAGTG
GTGGACATCGATGTCACCAAATACCTGGGCAAGGCGCAGAAACTCAACATCACCCTGCCAGGCTATTTGCTCAATCGTAT
CGATGAATACGTACTGCACCATCCCGAGGAAAAAAGCCGTTCGGGGTTCCTCGCGTCCGCAGCGCTCAAGGTGCTGCAAC
AGGATCGATAG

Structures

Toxin

• AlphaFold DB: A0A0R3AY05