Detailed information of TA system TA069930

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 695937..696533
• Replicon: chromosome
• Accession: NZ_CP018420
• Organism: Pseudomonas veronii strain R02

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: PverR02_RS03115
• Protein ID: WP_079442744.1
• Coordinates: 696231..696533 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3S0NU99
• Locus tag: PverR02_RS03110
• Protein ID: WP_046485673.1
• Coordinates: 695937..696227 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PverR02_RS03090	692309..694384	-	2076	WP_026140374.1	TonB-dependent copper receptor	-
PverR02_RS03095	694478..694903	-	426	WP_079442743.1	DUF2946 domain-containing protein	-
PverR02_RS03100	694915..695397	-	483	WP_046384861.1	copper chaperone PCu(A)C	-
PverR02_RS03105	695445..695840	-	396	WP_046485671.1	DUF2946 domain-containing protein	-
PverR02_RS03110	695937..696227	-	291	WP_046485673.1	putative addiction module antidote protein	Antitoxin
PverR02_RS03115	696231..696533	-	303	WP_079442744.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PverR02_RS03120	696890..697609	-	720	WP_079442745.1	cobalt-precorrin-6A reductase	-
PverR02_RS03125	697606..698811	-	1206	WP_079442746.1	precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE	-
PverR02_RS03130	698850..700202	+	1353	WP_079442747.1	precorrin-3B synthase	-
PverR02_RS03135	700195..700821	+	627	WP_046384855.1	precorrin-8X methylmutase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-96)

Antitoxin

• Uncharacterized protein HI1420 (5-94)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11549.43 Da
• Isoelectric Point: 9.1221

>T69930 WP_079442744.1 NZ_CP018420:c696533-696231 [Pseudomonas veronii]
MIEFEESIEFVKWLEAMRDPLAKVRIVTRLRMAQAGNFGDCEAVGEGVCEMRIHQGPGYRVYFTRRDKVVYLLLMGGDKS
TQSRDIQRAIHMAKNLGRKE

Nucleotide

• Length: 303 bp

>T69930 NZ_CP018420:c696533-696231 [Pseudomonas veronii]
ATGATTGAGTTCGAAGAATCCATTGAGTTTGTCAAATGGCTCGAAGCAATGCGCGATCCGCTCGCAAAAGTACGCATTGT
GACAAGGCTGCGCATGGCGCAAGCAGGAAACTTCGGCGACTGTGAGGCTGTAGGAGAGGGCGTTTGCGAAATGCGAATCC
ACCAAGGCCCCGGGTATCGGGTTTACTTCACTCGCCGAGACAAGGTGGTTTATCTGCTGCTGATGGGCGGCGACAAATCA
ACACAAAGCAGAGACATCCAGCGTGCAATACACATGGCAAAAAATCTTGGCCGCAAGGAGTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10408.99 Da
• Isoelectric Point: 5.8124

>AT69930 WP_046485673.1 NZ_CP018420:c696227-695937 [Pseudomonas veronii]
MSESFTRFDAAKYLKTPFEMAAYLDACFEEDAGDGLLIRTALNDIARAQGMTQVARDAGLGRESLYKALSSTGNPEFATI
MKVMKALGLKLHATAL

Nucleotide

• Length: 291 bp

>AT69930 NZ_CP018420:c696227-695937 [Pseudomonas veronii]
ATGAGCGAATCCTTTACCCGTTTCGATGCCGCAAAATATCTCAAGACTCCTTTTGAGATGGCCGCCTATCTGGATGCTTG
CTTTGAAGAAGATGCTGGCGACGGTCTGTTGATTCGCACAGCGTTGAACGATATCGCTCGCGCCCAAGGCATGACCCAAG
TCGCTCGCGACGCCGGCCTAGGACGAGAAAGTTTGTACAAAGCCCTCTCCAGCACTGGCAATCCCGAGTTCGCGACTATC
ATGAAAGTCATGAAAGCGCTGGGCCTCAAGCTTCACGCCACCGCGCTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A3S0NU99