Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2123116..2123771 Replicon chromosome
Accession NZ_CP018414
Organism Burkholderia pseudomallei strain 3000047530

Toxin (Protein)


Gene name relE Uniprot ID A0A0F6LEW6
Locus tag BOC59_RS11065 Protein ID WP_006027262.1
Coordinates 2123116..2123412 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag BOC59_RS11070 Protein ID WP_004202809.1
Coordinates 2123415..2123771 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOC59_RS11045 2118734..2119162 + 429 WP_143107362.1 helix-turn-helix domain-containing protein -
BOC59_RS11050 2119650..2120072 + 423 WP_143107363.1 DUF4145 domain-containing protein -
BOC59_RS11055 2120217..2121355 - 1139 Protein_1883 IS3 family transposase -
BOC59_RS11060 2121550..2122290 - 741 WP_157727026.1 hypothetical protein -
BOC59_RS11065 2123116..2123412 + 297 WP_006027262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BOC59_RS11070 2123415..2123771 + 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
BOC59_RS11075 2123815..2124870 - 1056 WP_143107365.1 phage portal protein -
BOC59_RS11080 2124867..2126636 - 1770 WP_143107366.1 terminase ATPase subunit family protein -
BOC59_RS11085 2126781..2127590 + 810 WP_071810901.1 GPO family capsid scaffolding protein -
BOC59_RS11090 2127624..2128637 + 1014 WP_071810902.1 phage major capsid protein, P2 family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2106719..2162189 55470


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10844.65 Da        Isoelectric Point: 10.1723

>T69923 WP_006027262.1 NZ_CP018414:2123116-2123412 [Burkholderia pseudomallei]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T69923 NZ_CP018414:2123116-2123412 [Burkholderia pseudomallei]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCGTGCGACGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT69923 WP_004202809.1 NZ_CP018414:2123415-2123771 [Burkholderia pseudomallei]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT69923 NZ_CP018414:2123415-2123771 [Burkholderia pseudomallei]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGGAACGTTGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6LEW6

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References