Detailed information of TA system TA069915

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 811270..811832
• Replicon: chromosome
• Accession: NZ_CP018408
• Organism: Burkholderia pseudomallei strain 2013833057

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: BOC55_RS04260
• Protein ID: WP_085507747.1
• Coordinates: 811270..811566 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3N4R2Q0
• Locus tag: BOC55_RS04265
• Protein ID: WP_038776176.1
• Coordinates: 811554..811832 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BOC55_RS04235	806539..806844	+	306	WP_123850029.1	hypothetical protein	-
BOC55_RS04240	806895..809015	+	2121	WP_085546303.1	DotA/TraY family protein	-
BOC55_RS04245	809025..809546	+	522	WP_085507752.1	hypothetical protein	-
BOC55_RS37905	809741..810400	-	660	WP_129112148.1	hypothetical protein	-
BOC55_RS04250	810501..810752	-	252	WP_197688523.1	hypothetical protein	-
BOC55_RS04255	810953..811273	-	321	WP_164978209.1	hypothetical protein	-
BOC55_RS04260	811270..811566	-	297	WP_085507747.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BOC55_RS04265	811554..811832	-	279	WP_038776176.1	CopG family ribbon-helix-helix protein	Antitoxin
BOC55_RS04270	811935..813941	-	2007	WP_085507862.1	relaxase/mobilization nuclease domain-containing protein	-
BOC55_RS04275	813947..814249	-	303	WP_157131343.1	mobilization protein	-
BOC55_RS04280	814706..814963	+	258	WP_085507743.1	hypothetical protein	-
BOC55_RS04285	815077..815598	+	522	WP_085507742.1	PAAR domain-containing protein	-
BOC55_RS04290	815595..816323	+	729	WP_085507740.1	VRR-NUC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	804697..825764	21067

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-96)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11067.55 Da
• Isoelectric Point: 9.5554

>T69915 WP_085507747.1 NZ_CP018408:c811566-811270 [Burkholderia pseudomallei]
MPQVIFAPAAIRDMQRLRDFLRPKNPDAARRAGEAIRQGVQALGTHPRMGRLVGDLPEQYREWPIDFGDSGYVARYRFDG
DGDAVTILAVRHQKEAGY

Nucleotide

• Length: 297 bp

>T69915 NZ_CP018408:c811566-811270 [Burkholderia pseudomallei]
ATGCCACAAGTAATCTTTGCGCCGGCGGCTATCCGGGATATGCAACGACTGCGGGACTTTCTGAGACCGAAGAATCCTGA
CGCCGCAAGGCGGGCTGGCGAAGCGATTAGACAAGGCGTACAGGCTCTCGGTACTCACCCTCGAATGGGACGTCTCGTAG
GAGATCTACCCGAGCAGTATCGGGAGTGGCCCATCGATTTCGGGGATAGTGGTTACGTGGCTCGGTACCGCTTCGATGGC
GATGGCGATGCCGTGACGATCTTGGCTGTCCGACACCAGAAGGAAGCGGGGTATTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10767.04 Da
• Isoelectric Point: 4.9654

>AT69915 WP_038776176.1 NZ_CP018408:c811832-811554 [Burkholderia pseudomallei]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNQDTLKAWDEFQATGLHATAEEVDKWLASWG
TENELPPPECHK

Nucleotide

• Length: 279 bp

>AT69915 NZ_CP018408:c811832-811554 [Burkholderia pseudomallei]
ATGGTTACGGCAACATCCATCAAGCTTGATGATGAACTGAAAGGGCGGGTTCAGCACTTGGCCGAGGCTCGTCGCCGCAC
CCCGCATTGGATCATGCGTGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGCGTTGAACCAGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCACGCGACCGCCGAGGAAGTGGATAAGTGGCTCGCGAGCTGGGGA
ACTGAAAACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A3N4R2Q0