Detailed information of TA system TA069912

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 3991241..3991803
• Replicon: chromosome
• Accession: NZ_CP018406
• Organism: Burkholderia pseudomallei strain 2013833055

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: BOC54_RS20760
• Protein ID: WP_085507747.1
• Coordinates: 3991507..3991803 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3N4R2Q0
• Locus tag: BOC54_RS20755
• Protein ID: WP_038776176.1
• Coordinates: 3991241..3991519 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BOC54_RS20730	3986750..3987478	-	729	WP_085507740.1	VRR-NUC domain-containing protein	-
BOC54_RS20735	3987475..3987996	-	522	WP_085507742.1	PAAR domain-containing protein	-
BOC54_RS20740	3988110..3988367	-	258	WP_085507743.1	hypothetical protein	-
BOC54_RS20745	3988824..3989126	+	303	WP_157131343.1	mobilization protein	-
BOC54_RS20750	3989132..3991138	+	2007	WP_085507862.1	relaxase/mobilization nuclease domain-containing protein	-
BOC54_RS20755	3991241..3991519	+	279	WP_038776176.1	CopG family ribbon-helix-helix protein	Antitoxin
BOC54_RS20760	3991507..3991803	+	297	WP_085507747.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BOC54_RS20765	3991806..3992120	+	315	WP_085507749.1	hypothetical protein	-
BOC54_RS20770	3992393..3992572	+	180	WP_085507751.1	hypothetical protein	-
BOC54_RS38890	3992673..3993332	+	660	WP_129112148.1	hypothetical protein	-
BOC54_RS20775	3993527..3994048	-	522	WP_085507752.1	hypothetical protein	-
BOC54_RS20780	3994058..3996232	-	2175	WP_085507754.1	DotA/TraY family protein	-
BOC54_RS20785	3996229..3996534	-	306	WP_123850029.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3977309..3998376	21067

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-96)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11067.55 Da
• Isoelectric Point: 9.5554

>T69912 WP_085507747.1 NZ_CP018406:3991507-3991803 [Burkholderia pseudomallei]
MPQVIFAPAAIRDMQRLRDFLRPKNPDAARRAGEAIRQGVQALGTHPRMGRLVGDLPEQYREWPIDFGDSGYVARYRFDG
DGDAVTILAVRHQKEAGY

Nucleotide

• Length: 297 bp

>T69912 NZ_CP018406:3991507-3991803 [Burkholderia pseudomallei]
ATGCCACAAGTAATCTTTGCGCCGGCGGCTATCCGGGATATGCAACGACTGCGGGACTTTCTGAGACCGAAGAATCCTGA
CGCCGCAAGGCGGGCTGGCGAAGCGATTAGACAAGGCGTACAGGCTCTCGGTACTCACCCTCGAATGGGACGTCTCGTAG
GAGATCTACCCGAGCAGTATCGGGAGTGGCCCATCGATTTCGGGGATAGTGGTTACGTGGCTCGGTACCGCTTCGATGGC
GATGGCGATGCCGTGACGATCTTGGCTGTCCGACACCAGAAGGAAGCGGGGTATTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10767.04 Da
• Isoelectric Point: 4.9654

>AT69912 WP_038776176.1 NZ_CP018406:3991241-3991519 [Burkholderia pseudomallei]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNQDTLKAWDEFQATGLHATAEEVDKWLASWG
TENELPPPECHK

Nucleotide

• Length: 279 bp

>AT69912 NZ_CP018406:3991241-3991519 [Burkholderia pseudomallei]
ATGGTTACGGCAACATCCATCAAGCTTGATGATGAACTGAAAGGGCGGGTTCAGCACTTGGCCGAGGCTCGTCGCCGCAC
CCCGCATTGGATCATGCGTGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGCGTTGAACCAGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCACGCGACCGCCGAGGAAGTGGATAAGTGGCTCGCGAGCTGGGGA
ACTGAAAACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A3N4R2Q0