Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 115175..115808 Replicon chromosome
Accession NZ_CP018391
Organism Burkholderia pseudomallei strain 2011756295

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BOC47_RS00550 Protein ID WP_085545764.1
Coordinates 115395..115808 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BOC47_RS00545 Protein ID WP_085545763.1
Coordinates 115175..115408 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOC47_RS00530 110611..112515 - 1905 WP_085545944.1 helicase/relaxase domain-containing protein -
BOC47_RS00535 112855..114429 + 1575 WP_164982130.1 MASE1 domain-containing protein -
BOC47_RS00540 114496..115176 - 681 WP_129112064.1 hypothetical protein -
BOC47_RS00545 115175..115408 + 234 WP_085545763.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BOC47_RS00550 115395..115808 + 414 WP_085545764.1 PIN domain-containing protein Toxin
BOC47_RS00555 115843..116205 + 363 WP_085545945.1 DUF3742 family protein -
BOC47_RS00560 116216..117721 - 1506 WP_085545765.1 conjugal transfer protein TraG N-terminal domain-containing protein -
BOC47_RS00565 117735..118076 - 342 WP_085545766.1 hypothetical protein -
BOC47_RS00570 118079..119548 - 1470 WP_129112110.1 integrating conjugative element protein -
BOC47_RS00575 119500..120441 - 942 WP_085545767.1 TIGR03756 family integrating conjugative element protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-120)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15337.79 Da        Isoelectric Point: 6.0839

>T69898 WP_085545764.1 NZ_CP018391:115395-115808 [Burkholderia pseudomallei]
MSGADKAKVFVDSNVVLYLLSGDTAKADRAEALLRRRPTISVQVLNEVTNVCVRKLGMAWREVEQFLELVRQFCVVAPLT
IEMHDLARRIAERYGLAFYDACIVAAASIEGCHALYTEDMHHGLIIEESLTLRNPFA

Download         Length: 414 bp

>T69898 NZ_CP018391:115395-115808 [Burkholderia pseudomallei]
ATGAGCGGGGCTGACAAGGCGAAAGTATTTGTGGACAGCAACGTCGTGCTGTATCTGTTGTCCGGTGATACCGCGAAGGC
GGATCGTGCGGAGGCTCTGTTGCGGCGCCGCCCGACGATCAGCGTCCAGGTGCTGAACGAAGTCACGAACGTCTGCGTGC
GTAAGCTCGGTATGGCGTGGCGTGAGGTCGAACAGTTCTTGGAACTGGTGCGGCAGTTTTGTGTGGTCGCGCCGCTTACA
ATCGAGATGCATGATTTGGCGCGGCGCATCGCCGAACGCTATGGTCTGGCGTTCTATGATGCGTGCATCGTAGCAGCCGC
GTCGATCGAAGGATGCCACGCCCTCTACACGGAAGACATGCATCACGGATTGATCATCGAAGAGAGCTTGACGCTGCGTA
ACCCTTTCGCGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8732.97 Da        Isoelectric Point: 7.0164

>AT69898 WP_085545763.1 NZ_CP018391:115175-115408 [Burkholderia pseudomallei]
MQVAKWGNSLAVRLPSSLVEALELREGDDIEIVIDAPRTFAVRKKPGADELLERLRHFRGKLPADFKFSRDEANERG

Download         Length: 234 bp

>AT69898 NZ_CP018391:115175-115408 [Burkholderia pseudomallei]
ATGCAGGTTGCTAAATGGGGCAATAGCCTTGCCGTCCGCCTTCCGTCGAGCCTGGTCGAAGCGCTCGAGCTGCGTGAGGG
GGACGATATCGAGATCGTCATAGACGCGCCGCGCACCTTTGCAGTACGCAAGAAGCCGGGGGCGGATGAACTGCTGGAGC
GGTTGCGCCACTTCCGCGGCAAGCTGCCGGCTGATTTCAAGTTCAGCCGGGACGAGGCGAATGAGCGGGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References