Detailed information of TA system TA069887

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 4019210..4019766
• Replicon: chromosome
• Accession: NZ_CP018383
• Organism: Burkholderia pseudomallei strain 2008724758

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: BOC43_RS37430
• Protein ID: WP_076887903.1
• Coordinates: 4019210..4019500 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BOC43_RS37435
• Protein ID: WP_076887904.1
• Coordinates: 4019488..4019766 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BOC43_RS37405	4015181..4015825	+	645	WP_145956738.1	hypothetical protein	-
BOC43_RS39170	4015815..4016885	+	1071	WP_145956739.1	hypothetical protein	-
BOC43_RS37410	4016874..4018214	-	1341	WP_197690680.1	SAM-dependent methyltransferase	-
BOC43_RS37415	4018375..4018626	-	252	WP_172409070.1	hypothetical protein	-
BOC43_RS40130	4018706..4018900	-	195	WP_172409071.1	hypothetical protein	-
BOC43_RS37425	4018893..4019213	-	321	WP_076887902.1	hypothetical protein	-
BOC43_RS37430	4019210..4019500	-	291	WP_076887903.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BOC43_RS37435	4019488..4019766	-	279	WP_076887904.1	CopG family ribbon-helix-helix protein	Antitoxin
BOC43_RS37440	4019869..4021875	-	2007	WP_085547897.1	relaxase/mobilization nuclease domain-containing protein	-
BOC43_RS37445	4021882..4022184	-	303	WP_076887910.1	ribbon-helix-helix protein, CopG family	-
BOC43_RS37450	4022639..4022896	+	258	WP_076887911.1	hypothetical protein	-
BOC43_RS37455	4023114..4024274	+	1161	WP_085547846.1	IS30 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	4007797..4029683	21886
	-	flank	IS/Tn	-	-	4023114..4024274	1160

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10947.47 Da
• Isoelectric Point: 9.5554

>T69887 WP_076887903.1 NZ_CP018383:c4019500-4019210 [Burkholderia pseudomallei]
MPQVIFAPAAIQDMQRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRLGRLIEDLPEQYREWPIDFGDSGYVARYRFDG
DAVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T69887 NZ_CP018383:c4019500-4019210 [Burkholderia pseudomallei]
ATGCCACAAGTAATCTTTGCGCCGGCAGCAATCCAAGACATGCAACGGCTGCGTGAATTCCTGAGACCGAAGAATCCTGA
CGCCGCGAGGCGGGCCGGTGAAGCGATCAGACGCGGCGTCCAAGCTCTCGGCGCCCACCCTCGGTTGGGGCGTCTCATAG
AAGATCTGCCTGAGCAGTATCGGGAGTGGCCCATCGATTTCGGGGATAGTGGTTACGTGGCTCGGTACCGCTTCGATGGC
GATGCCGTCACGATCTTGGCTGTCCGACACCAGAAGGAAGCGGGGTATTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10824.14 Da
• Isoelectric Point: 4.9823

>AT69887 WP_076887904.1 NZ_CP018383:c4019766-4019488 [Burkholderia pseudomallei]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TEDELPPPECHK

Nucleotide

• Length: 279 bp

>AT69887 NZ_CP018383:c4019766-4019488 [Burkholderia pseudomallei]
ATGGTTACGGCAACATCTATCAAGCTTGATGATGAACTGAAAGGGCGGGTTCAACACTTGGCCGAGGCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATCGAGCAGTACGTCGAGCGCGAGGAAAAGCGAGAGGCGCTGAACCGGGACACGC
TGAAAGCGTGGGATGAATTTCAGGCGACTGGCCTGCATGTGACTGCTGAGGAAGTGGACAAGTGGCTCGCGAGCTGGGGA
ACTGAAGACGAACTGCCTCCGCCGGAATGCCACAAGTAA