69885

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 870973..871628 Replicon chromosome
Accession NZ_CP018383
Organism Burkholderia pseudomallei strain 2008724758

Toxin (Protein)


Gene name relE Uniprot ID A0A0F6LEW6
Locus tag BOC43_RS20995 Protein ID WP_006027262.1
Coordinates 870973..871269 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag BOC43_RS21000 Protein ID WP_004202809.1
Coordinates 871272..871628 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOC43_RS20970 866291..866656 + 366 WP_009922432.1 phage virion morphogenesis protein -
BOC43_RS20985 868430..869004 - 575 Protein_795 DUF4276 family protein -
BOC43_RS20990 869049..870305 - 1257 WP_004552667.1 AAA family ATPase -
BOC43_RS20995 870973..871269 + 297 WP_006027262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BOC43_RS21000 871272..871628 + 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
BOC43_RS21005 871672..872727 - 1056 WP_085547557.1 phage portal protein -
BOC43_RS21010 872724..873221 - 498 WP_004199888.1 terminase -
BOC43_RS21020 873443..873964 - 522 WP_004199890.1 ClpXP protease specificity-enhancing factor -
BOC43_RS21025 874034..874645 - 612 WP_004185176.1 glutathione S-transferase N-terminal domain-containing protein -
BOC43_RS21030 874738..875496 - 759 WP_004521940.1 cytochrome c1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 866291..873038 6747


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10844.65 Da        Isoelectric Point: 10.1723

>T69885 WP_006027262.1 NZ_CP018383:870973-871269 [Burkholderia pseudomallei]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T69885 NZ_CP018383:870973-871269 [Burkholderia pseudomallei]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGGCGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT69885 WP_004202809.1 NZ_CP018383:871272-871628 [Burkholderia pseudomallei]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT69885 NZ_CP018383:871272-871628 [Burkholderia pseudomallei]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6LEW6

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References