69875

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1660635..1661290 Replicon chromosome
Accession NZ_CP018373
Organism Burkholderia pseudomallei strain 2002721184

Toxin (Protein)


Gene name relE Uniprot ID A0A7U5JZW6
Locus tag BOC38_RS08780 Protein ID WP_009969693.1
Coordinates 1660994..1661290 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U5K0U1
Locus tag BOC38_RS08775 Protein ID WP_009969692.1
Coordinates 1660635..1660991 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOC38_RS08755 1655770..1656783 - 1014 WP_009969688.1 phage major capsid protein, P2 family -
BOC38_RS08760 1656817..1657626 - 810 WP_009969689.1 GPO family capsid scaffolding protein -
BOC38_RS08765 1657770..1659539 + 1770 WP_009969690.1 terminase ATPase subunit family protein -
BOC38_RS08770 1659536..1660591 + 1056 WP_009969691.1 phage portal protein -
BOC38_RS08775 1660635..1660991 - 357 WP_009969692.1 putative addiction module antidote protein Antitoxin
BOC38_RS08780 1660994..1661290 - 297 WP_009969693.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BOC38_RS08785 1661900..1662637 - 738 WP_076852952.1 dCTP deaminase -
BOC38_RS38085 1662638..1663957 - 1320 WP_143293235.1 hypothetical protein -
BOC38_RS08790 1663970..1664404 - 435 WP_143293234.1 hypothetical protein -
BOC38_RS08795 1664480..1664926 - 447 WP_076852949.1 MerR family transcriptional regulator -
BOC38_RS08800 1665466..1665894 - 429 WP_038722429.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1638054..1677909 39855


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(5-92)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10888.66 Da        Isoelectric Point: 10.0996

>T69875 WP_009969693.1 NZ_CP018373:c1661290-1660994 [Burkholderia pseudomallei]
MYKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGRIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T69875 NZ_CP018373:c1661290-1660994 [Burkholderia pseudomallei]
ATGTACAAAGTCCTGACGACCCCCCAATTTGACAAATGGCTTGACGGGCTTCGCGACCCGGTCGGTAGCGCGGCGATCAA
CCTGCGCATCGAGCGGGCAAAGCTTGGCAATCTCGGCCAATGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCGTGCGACGCGGAAGAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTGGCGAAGCAAATCGCCGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12671.50 Da        Isoelectric Point: 9.5609

>AT69875 WP_009969692.1 NZ_CP018373:c1660991-1660635 [Burkholderia pseudomallei]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEDGNAEFATIM
KVVGALGLHLTVAPVEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT69875 NZ_CP018373:c1660991-1660635 [Burkholderia pseudomallei]
ATGAAAATCAGCGAACTGGCCGAGTTCGATGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAATCCGCGCCTGATTCAAGCCGCGCTTGGAAACGTTGCGAAGGCGCGCGGCATGACGGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTACCGCGCGCTGTCGGAAGATGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACTTGACCGTTGCGCCGGTCGAACCTGCGCCGGTGCCCGCGCCGGCGACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U5JZW6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U5K0U1

References