Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4828915..4829431 Replicon chromosome
Accession NZ_CP018364
Organism Klebsiella pneumoniae strain Kp_Goe_62629

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag BB790_RS25405 Protein ID WP_004178374.1
Coordinates 4828915..4829199 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag BB790_RS25410 Protein ID WP_002886901.1
Coordinates 4829189..4829431 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB790_RS25375 4824332..4824640 - 309 WP_019725542.1 PTS sugar transporter subunit IIB -
BB790_RS32460 4824725..4824898 + 174 WP_019725541.1 hypothetical protein -
BB790_RS25385 4824901..4825644 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
BB790_RS25395 4826001..4828139 + 2139 WP_019725540.1 anaerobic ribonucleoside-triphosphate reductase -
BB790_RS25400 4828447..4828911 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
BB790_RS25405 4828915..4829199 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BB790_RS25410 4829189..4829431 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BB790_RS25415 4829509..4831419 - 1911 WP_019725539.1 BglG family transcription antiterminator -
BB790_RS25420 4831442..4832596 - 1155 WP_004178372.1 lactonase family protein -
BB790_RS25425 4832663..4833403 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T69865 WP_004178374.1 NZ_CP018364:c4829199-4828915 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T69865 NZ_CP018364:c4829199-4828915 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCTGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT69865 WP_002886901.1 NZ_CP018364:c4829431-4829189 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT69865 NZ_CP018364:c4829431-4829189 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References